Synthesis ofthe Natural Product

The synthetic utility of the present transformation is highlighted by the deriva tization of the furyl ring to form y butenolide (Scheme 3.17). As the y butenolide architecture is a common building block in the synthesis of various natural products, the F C reaction product represents a new entry to the synthetic precursors of nitrogen containing molecules. The aza Achmatowicz reaction, followed by reduc tive cyclization ofthe 1,4 dicarbonyl intermediate under Luche conditions, produced the y butenolide in good yield. 

Physical solvent processes give some, but not all, ofthe above qualities. The Selexol process has several industrial applications, most of them for synthesis gas deacidification and some for natural gas treatment [6-8]. A methanol-based refrigerated solvent process such as the Ifpex-2 process from the Ifpexol technology matrix ofIFP is also a good contender [9]. However, physical solvents have a high affinity for hydrocarbons and the separated acid gas stream contains large quantities of valuable hydrocarbon products. 

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