Larock indole synthesis natural products

In addition, the synthesis of 6-methoxytrypophan 129 was achieved under similar conditions of the larock indole synthesis. Intermediate 129 is one of the key starting reagents for the synthesis of other natural products as demonstrated by Cook and co-workers. ... 

A general approach to 3,4-fused indoles via an intramolecular Larock indole synthesis was reported by Jia. A large range of ring sizes, from 6 to 18, was demonstrated to result in moderate-to-excellent yields with reasonable functional group compatibility. The study culminated in the total synthesis of the natural product fargesine (141, 8 steps, 15% overall yield) (13AG(I)4902). 

The Boger laboratory has reported on studies directed toward the total synthesis of chloropeptins, natural products which display anti-HIV activity through inhibition of gp 120-CD4 binding, that relied on the use of an intramolecular Larock indole synthesis to effect macrocyclization of 124 to give 125 (Scheme 11.15, DtBPF (l,l -bis(di-te/t-butylphosphino)ferrocene). Subsequent detailed investigations resulted in further improvements in the optimal conditions for the transformation, which also has the potential to provide a route to complex ring systems in de novo macrocycles. ... 

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