Domino Reactions in the Total Synthesis of Natural Products

Domino Reactions in the Total Synthesis of Natural Products 

Svenia-C. Dufert, Judith Hierold, and Lutz F. Tietze 

While all the diverse fields and aspects of organic chemistry, including methodology, bioorganic chemistry, and material sciences, constantly evolve and grow in importance in both academic and industrial research, the total synthesis of natural products can still be considered the masterpiece of the area. 

During the last decades, the number of total syntheses featuring domino reactions has increased exponentially. Accordingly, numerous reviews and book chapters have been dedicated to the subject. Thus, we do not aim to be comprehensive in the following survey on total syntheses, but rather want to give an overview of the most recent elegant examples, which not only meet the definition of domino reactions but also provide a maximum increase in structural complexity. 

As was the case in our earlier publications, the total syntheses described herein were classified according to the first step of the domino process they feature. Hence, the distinction has been made between cationic, anionic, radical, pericyclic, transition-metal-catalyzed, and reductive or oxidative domino processes. 

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