Diversity-oriented Synthesis of Natural-product-like Libraries

Diversity-oriented Synthesis of Natural-product-like Libraries... 

S. Shang, D.S. Tan, Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries, Curr. Opin. Chem. Biol. 2005, 9, 248-258. 

FIGURE 11.73 Diversity-oriented synthesis of a galanthamine-based library. (From Pelish, H.E. et al., Use of biomimetic diversity-oriented synthesis to discover galanthamine-like molecules with biological properties beyond those of the natural product, J. Am. Chem. Soc., 123, 6740, 2001.)... 

The power of furan has long been appreciated in target-oriented synthesis and more recently in diversity-oriented synthesis. Schreiber has made elegant use of the embedded diversity in this heterocycle to build complex, natural product-like libraries <03SCI1613 04JA14095> (Scheme... 

Natural epothilones have been structurally modified by various teams, making use of the broad stractural scope of natural product-based drag discovery in this field. Generally, this approach includes the de novo construction of libraries of natural product-like compoimds through diversity orientated synthesis (DOS) [17]. A concept for the design of natiual product-based libraries, introduced by H. Waldmann [18], has been developed over the last few years [19] (see also Sects. 1.2.1 and 1.2.2 in the introductory chapter). 

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