Natural Product and Bioactive Compound Synthesis

Bridged bicycloketones are attractive substrates due to the structural complexity of the scaffolds. The high chemoselectivity of the biotransformation for the carbonyl oxygenation allows for a functional decoration without the need for elaborate protection strategies. Subsequent chemical elaboration of the biooxidation products opens up rapid and efficient novel synthetic pathways towards various target compounds. 

Biotransformation of hetero-bicyclic ketone 8 enabled access to unsaturated lactone 9 in a desymmetrization reaction without compromising the olefin func- 

The typical S-oxidation with BVMOs allows the formation of chiral sulfoxides from organic sulfides. This oxidation has received much interest in organic chemistry due to its use in the synthesis of enantiomerically enriched materials as chiral auxiliaries or directly as biologically active ingredients. This reaction has been studied extensively with CHMO from Adnetohacter showing high enantioselectivi-ties in the sulfoxidation of alkyl aryl sulfides, disulfides, dialkyl sulfides, and cychc and acyclic 1,3-dithioacetals [90]. CHMO also catalyzes the enantioselective oxida-hon of organic cyclic sulfites to sulfates [91]. 

Moreover, the e.e. of the sulfoxide products changes with the progress of the reaction indicating that the PAMO was able to catalyze the kinetic resolution of the sulfoxide to the sulfone. The enantiomeric ratio measured with methyl phenethyl sulfoxide was 110. Previous studies carried out with CHMO revealed 

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