Synthesis of Natural Products in an Efficient Manner

MCRs are convergent reactions in which three or more components react to form a single product. They therefore offer means to construct complex and stracturaUy diverse compounds in an almost simple and elegant manner (Fig. 6.3). 

SCHEME 6.4 MCR chemistry combined with biocatalysis in the synthesis of telaprevir 47. 

FIGURE 6.3 MCRs as powerful tool for natural products synthesis [22-26]. 

SCHEME 6.5 Synthesis of key fragment 60 in the total synthesis of ecteinascidin 743 48, using the Ugi multicomponent reaction. 

SCHEME 6.8 Three-component [4+2]/[2+2] cycloaddition cascade in the total synthesis of paesslerin A 52. 

---