Cascade reactions in natural product synthesis

Overman and Pennington have developed a versatile methodology for stereoselective tetrahydrofuran synthesis based on pinacol terminated Prins cyclizations. The general reaction is outlined in Scheme 63. A review on the strategic use of these cascade reactions in natural product synthesis has been published <2003JOC7143>. [Pg.535]

The purpose of this chapter is to describe the use of epoxides as biosynthetic precursors for cyclic ethers. The advances that allow for predictable chemical synthesis based on epoxide opening, including the development of models for regiocontrol in intramolecular ring-opening reactions and stereoselective synthesis, will be described. Numerons examples of epoxide cascade reactions in natural product synthesis will conclude the chapter. [Pg.162]

APPLICATION OF ORGANOCATALYTIC CASCADE REACTIONS IN NATURAL PRODUCT SYNTHESIS AND DRUG DISCOVERY... [Pg.123]

Amine-catalyzed cascade reactions in natural product synthesis... [Pg.123]

Iminium-Ion-Catalyzed Cascade Reactions in Natural Product Synthesis... [Pg.125]

The first three chapters focus on organocatalytic cascade reactions, including amines, and Brpnsted acids, and the use of organocatalytic cascade reactions in natural product synthesis and drug discovery. Subsequent chapters introduce new developments and progress in transition metal cascade catalysis. Gold- and platinum-catalyzed... [Pg.442]