N-methyl-D-asparte receptors

Cruz SE, Mirshahi T, Thomas B, et al Effects of the abused solvent toluene on recombinant N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther 286 334-340, 1998 De Rosa E, Bartolucci GB, Sigon M, et al Hippuric acid and ortho-cresol as biological indicators ofoccupational exposure to toluene. Am J Ind Med 11 529—537,1987 Delteil P, Stoesser F, Stoesser R L theromanie. Ann Med Psychol (Paris) 1 329-340, 1974... 

Bachis A, Mocchetti I (2004) The chemokine receptor CXCR4 and not the N-methyl-D-aspartate receptor mediates gpl20 neurotoxicity in cerebellar granule cells. J Neurosci Res 75(1) 75-82... 

Lynch DR, Guttmann RP (2002) Excitotoxicity perspectives based on N-methyl-D-aspartate receptor subtypes. J Pharmacol Exp Ther 300(3) 717-723 Magnuson DS, Knudsen BE, Geiger JD, Brownstone RM, Nath A (1995) Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity. Ann Neurol 37(3) 373-380 Mamdouh Z, Chen X, Kerini LM, Maxfield FR, Muller WA (2003) Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis. Nature 421(6924) 748-753... 

Pittalnga A, Pattarini R, Severi P, Raiteri M (1996) Hnman brain N-methyl-D-aspartate receptors regnlating noradrenaline release are positively modnlated by HIV-1 coat protein gpl20. Aids 10(5) 463 68... 

Xin KQ, Hamajima K, Hattori S, Cao XR, Kawamoto S, Okuda K (1999) Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system. AIDS Res Hum Retroviruses 15(16) 1461-1467... 

Glutamatergic AMPA (a-amino-3-hydroxy-5-methyM-isoxazolpropionic acid) and NMDA (N-methyl-D-aspartate) receptors are also found together with glutamatergic inputs from the LH (Yang Hatton, 1997), although the physiological role of this excitation remains unclear (Haas Panula, 2003). 

Fedele, E., Varnier, G., Ansaldo, M.A., Raiteri, M. Nicotine administration stimulates the in vivo N-methyl-D-aspartate receptor/nitric oxide/cyclic GMP pathway in rat hippocampus through glutamate release. Br. J. Pharmacol. 125 1042, 1998. 

Nonaka S, Chuang DM. Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N -methyl-D-aspartate receptor-mediated calcium influx. Proc Natl Acad Sci USA 1998 95 2642-2647. 

Huang, Y. S., Jung, M. Y., Sarkissian, M., and Richter, J. D. (2002). N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapses. EMBOJ. 21, 2139-2148. 

Glycine is inhibitory on ligand-gated, strychnine-sensitive Ch channel receptors but excitatory on N-methyl-D-aspartate receptors 298... 

Lau, L. F. and Huganir, R. L. Differential tyrosine phosphorylation of N-methyl-D-aspartate receptor subunits. /. Biol. Chem. 270 20036-20041,1995. 

Moon, I. S., Apperson, M. L. and Kennedy, M. B. The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B. Proc. Natl Acad. Sci. U.S.A. 91 3954-3958,1994. 

Tezuka, T., Umemori, H., Akiyama, T. et al. PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A. Proc. Natl Acad. Sci. U. S. A. 96 435-440,1999. 

FIGURE 32-3 Changes in intracellular and extracellular Ca2+ during ischemia-reperfusion and the effects of the N-methyl-D-aspartate receptor antagonist MK-801. Intracellular Ca2+, circles, extracellular Ca2+, squares with MK-801, orange, without MK-801, blue. (From Silver and Erecinska, in [3].)... 

Krystal, J. H., Petrakis, I. L., Mason, G., Trevisan, L. and D Souza, D. C. N-methyl-D-aspartate receptors and alcoholism reward, dependence, treatment, and vulnerability. Pharmacol. Therap. 99 79-94,2003. 

Zinc is important to the normal functioning of the central nervous system (CNS). At low concentrations, zinc protects mammalian brain neurons by blocking N-methyl-D-aspartate receptor-mediated toxicity. At high concentrations, zinc is a potent, rapidly acting neurotoxicant in the mammalian brain, as judged by zinc-induced neuronal injury of in vitro mature cortical cell cultures (Choi et al. 1988). Increased brain levels of zinc are associated with Pick s disease in certain strains of rodents with inherited epileptic seizures. Intravenous injection of zinc in rats with genetically inherited epilepsy produces seizures a similar response occurs with intracranial injection of zinc in rabbits with inherited audiogenic seizures (Choi et al. 1988). 

Memantine (Namenda) blocks glutamatergic neurotransmission by antagonizing N-methyl-D-aspartate receptors, which may prevent excitotoxic reactions. It is used as monotherapy, and data suggest that when it is combined with a cholinesterase inhibitor, there is improvement in cognition and activities of daily living. 

Chen, N., Moshaver, A., and Raymond, L. A. (1997) Differential sensitivity of recombinant N-methyl-D-aspartate receptor subtypes to zinc inhibition. Mol. Pharmacol. 51, 1015-1023. 

Gunasekar PG, Sun PW, Kanthasamy AG, etal. 1996. Cyanide-induced neurotoxcity involves nitric oxide and reactive oxygen species generation after N-Methyl-D-aspartate receptor activation. The Journal of Pharmacology and Experimental Therapeutics 277 150-155. 

Patel MN, Yim GK, Isom GE. 1993. N-methyl-D-aspartate receptors mediate cyanide-induced cytotoxicity in hippocampal cultures. Neurotoxicology 14(l) 35-40. 

Patel MN, Yim GKW, Isom GE. 1992. Blockade of N-methyl-D-aspartate receptors prevents cyanide-induced neuronal injury in primary hippocampal cultures. Toxicol Appl Pharmacol 115 124-129. 

Moaddel, R., Clorx, J.-F., Ertem, G., Wainer, I. W. Multiple receptor liquid chromatographic stationary phases the co-immobilization of nicotinic receptors, y-amino-butyric acid receptors, and N-methyl-D-aspartate receptors. Pharm Res 2002, 19, 104-107. 

Bach, A., Chi, C.N., Olsen, T.B., Pedersen, S.W., Roder, M.U., Pang, G.F., Clausen, R.P., Jemth, P. and Stromgaard, K. (2008) Modified Peptides as Potent Inhibitors offhe Postsynaptic Density-95/ N-Methyl-d-Aspartate Receptor Interaction. Journal of Medicinal Chemistry, 51, 6450-6459. 

Morris RGM (1989) Synaptic plasticity and learning selective impairment of learning in rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist APS. J Neurosci 9 3040-3057... 

Breese CR, Freedman R, Leonard SS (1995) Glutamate receptorsubtype expression in human postmortem brain tissue from schizophrenics and alcohol abusers. Brain Res 674 82-90 Bristow LJ, Flatman KL, Hutson PH, et al (1996) The atypical neuroleptic profile of the glycine/N-methyl-D-aspartate receptor antagonist, 1-701,324, in rodents. J Pharmacol Exp Ther 277 578-585... 

Dempsey RJ, BaskayaMK, Dogan A (2000) Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-d-aspartate receptor antagonist, after experimental traumatic brain injury in rats. Neurosurgery 47 399-404... 

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