N-methyl-D-aspartate receptor antagonists

FIGURE 32-3 Changes in intracellular and extracellular Ca2+ during ischemia-reperfusion and the effects of the N-methyl-D-aspartate receptor antagonist MK-801. Intracellular Ca2+, circles, extracellular Ca2+, squares with MK-801, orange, without MK-801, blue. (From Silver and Erecinska, in [3].)... 

Morris RGM (1989) Synaptic plasticity and learning selective impairment of learning in rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist APS. J Neurosci 9 3040-3057... 

Breese CR, Freedman R, Leonard SS (1995) Glutamate receptorsubtype expression in human postmortem brain tissue from schizophrenics and alcohol abusers. Brain Res 674 82-90 Bristow LJ, Flatman KL, Hutson PH, et al (1996) The atypical neuroleptic profile of the glycine/N-methyl-D-aspartate receptor antagonist, 1-701,324, in rodents. J Pharmacol Exp Ther 277 578-585... 

Dempsey RJ, BaskayaMK, Dogan A (2000) Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-d-aspartate receptor antagonist, after experimental traumatic brain injury in rats. Neurosurgery 47 399-404... 

Anand A, Charney DS, Oren DA. Attenuation of the neuropsychiatric effects of ketamine with lamotrigine. Support for hyperglutamatergic effects of N -methyl-D-aspartate receptor antagonists. Arch Gen Psychiatry 2000 57 270-276. 

Fischer BD, Carrigan KA, Dykstra LA Effects of N-methyl-D-aspartate receptor antagonists on acute morphine-induced and L-methadone-induced antinociception in mice. 3 Pain 2005 6 425. [PMID 15993820]... 

Eisenach, J. C. and Gebhart, G. F. Intrathecal amitriptyline acts as an N-methyl-D-aspartate receptor antagonist in the presence of inflammatory hyperalgesia in rats, Anesthesiology 1995, 83, 1046-1054. 

Allen, R. M. and Dykstra, L. A. N-Methyl-D-aspartate receptor antagonists potentiate the antinociceptive effects of morphine in squirrel monkeys, J. Pharmacol. Exp. Ther. 2001, 298, 288-297. 

Doyle, K. M., Feerick, S., Kirkby, D. L., Eddleston, A., Higgins, G. A. Comparison of various N-methyl-D-aspartate receptor antagonists in a model of short-term memory and a overt behaviour, Behav. Pharmacol. 1998, 9, 671-681. 

Eisenberg, E., Kleiser, A., Dortort, A., Haim, T., Yarnitsky, D. The NMDA (N-methyl-D-aspartate) receptor antagonist memantine in the treatment of postherpetic neuralgia a double-blind, placebo-controlled study, Eur. J. Pain 1998, 2, 321-327. 

Grass, S., Hoffmann, O., Xu, X.-J., Wiesenfeld-Hallin, Z. N-Methyl-D-aspartate receptor antagonists... 

Honore, P., Chapman, V., Buritova, J., Besson, J.-M.. Concomitant administration of morphine and an N-methyl-D-aspartate receptor antagonist profoundly reduces inflammatory evoked spinal c-Fos expression, Anaesthesiology 1996, 85, 150-160. 

Nikolajsen, L., Gottrup, H., Kristensen, A. G. D., Jensen, T. S. Memantine (a N-methyl-D-aspartate receptor antagonist) in the treatment of neuropathic pain after amputation or surgery a randomized, double-blinded, cross-over study, Anesth. Analg. 2000, 97, 960-966. 

Plesan, A., Sollevi, A., Segerdahl, M. The N-methyl-D-aspartate-receptor antagonist dextromethorphan lacks analgesic effect in a human experimental ischemic pain model, Acta Anaesthesiol. Scand. 2000, 44, 924-928. 

Price, D. D., Mao, J., Frenk, H., Mayer, D. J. The N-methyl-D-aspartate receptor antagonist... 

P. D., Marshall, G. R., Oles, R. J., Priestley, T., Thorn, L., Tricklebank, M. D., Vass, C. A., Williams, B. J. Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent g-butyrolactone-like sedative, Proc. Natl. Acad. Sci. USA 1990, 87, 347-351. 

Tiseo, P. L. and Inturrisi, C. E. Attenuation and reversal of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist, LY274614, J. Pharmacol. Exp. Ther. 1993, 264, 1090-1096. 

Perkins, M., Rudin, M., Sauter, A., Wiederhold, K.-H., Muller, W. Biphenyl-derivatives of2-amino-7-phosphono-heptanoic acid A novel class of potent competitive N-methyl-D-aspartate receptor antagonists II. Pharmacological characterization in vivo, Neuropharmacology 1996, 35, 655-669. 

Morris, R. G., Anderson, E., Lynch, G. S., and Baudry, M. (1986). Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature 319, 774-776. 

Kos, T., Legutko, B., Danysz, W., Samor-iski, G., and Popik, P. (2006) Enhancement of antidepressant-like effects but not brain-derived neurotrophic factor mRNA expression by the novel N-methyl-D-aspartate receptor antagonist neramexane in mice Behav Pharmacol 318, 1128-1136. 

The First Total Synthesis and Mode of Action of N-Methyl-D-aspartate Receptor Antagonists, ES-242s... 

Javitt DC, Jotkowitz A, Sircar R, Zukin SR. 1987. Noncompetitive regulation of phencyclidine/sigma-receptors by the N-methyl-D-aspartate receptor antagonist D-(-)-2-amino-5-phosphonovaleric acid. Neurosci Lett... 

Pharmacokinetic and pharmacodynamic data from an open study in 24 healthy subjects suggested that there is no interaction between memantine (an N-methyl-D-aspartate receptor antagonist approved for treatment of... 

McCartney C, Sinha A, Katz J. A qualitative systematic review of N-methyl-D-aspartate receptor antagonists in preventive analgesia. Anesth Analg 2004 98 1385 100. 

Methadone has regained prominence in treating cancer pain. It has a prolonged mechanism of action, N-methyl-D-aspartate receptor antagonist activity (d-isomer), and is inexpensive. However, it can be difficult to titrate. 

Allen, R. M., Granger, A. L., Sc Dykstra, L. A. (2003). The competitive N-methyl-D-aspartate receptor antagonist (-)-6 phosphonomethyl -deca -... 

Anti-dementia drug N-methyl-D-aspartate receptor antagonist... 

S,47 ) -Hydroxypipecolic acid [(-)-a3 -4-hydroxy-2-piperidine carboxylic acid, 3] was isolated from the leaves of Calliandra piuieri and Strophantus scandeus and it was identified as a constituent of cyclopeptide antibiotics, such as virginiamycin S2. It was also employed as a precursor in the preparation of selective N-methyl-D-aspartate receptor antagonists. Furthermore, (-)-3 has served as a building block in a recent synthesis of palinavir, a potent peptidomimetic-based HIV protease inhibitor. ... 

Warncke T, Jorum E, Stubhaug A. Local treatment with the N-methyl-D-aspartate receptor antagonist ketamine, inhibit development of secondary hyperalgesia in man by a peripheral action. Neurosci Lett 1997 227(l) l-4. 

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