Reactive oxygen species generation

Kim, K., Rhee, S.G., and Stadtman, E.R. (1985) Nonenzymatic cleavage of proteins by reactive oxygen species generated by dithiothreitol and iron./. Biol. Chem. 260, 15394-15397. 

Oxygen free radicals are required intermediates in many biological reactions but may damage macromolecules during oxidative stress 566 Reactive oxygen species generated during ischemia—reperfusion contribute to the injury 567... 

Gunasekar PG, Sun PW, Kanthasamy AG, etal. 1996. Cyanide-induced neurotoxcity involves nitric oxide and reactive oxygen species generation after N-Methyl-D-aspartate receptor activation. The Journal of Pharmacology and Experimental Therapeutics 277 150-155. 

Mattia, C.J., LeBel, C.P. Bondy, S.C. (1991) Effects of toluene and its metabolites on cerebral reactive oxygen species generation. Biochem. Pharmacol., 42, 879-882... 

Architecture of succinate dehydrogenase and reactive oxygen species generation. Science 299, 700-704. 

Kahlert S., Zundorf G., and Reiser G. (2005). Glutamate-mediated influx of extracellular Ca2+ is coupled with reactive oxygen species generation in cultured hippocampal neurons but not in astrocytes. J. Neurosci. Res. 79 262-271. 

Viviani B., Corsini E., Binaglia M., Galli C. L., and Marinovich M. (2001). Reactive oxygen species generated by glia are responsible for neuron death induced by human immunodeficiency virus-glycoprotein 120 in vitro. Neuroscience 107 51-58. 

Halleen, J.M., Raisanen, S., Salo, J.J., Reddy, S.V., Roodman, G.D., Hentunen, T.A., Lehenkari, P.P., Kaija, H., Vihko, P., and Vaananen, H.K. 1999. Intracellular fragmentation of bone resorption products by reactive oxygen species generated by osteoclastic tartrate-resistant acid phosphatase. J. Biol. Chem. 274, 22907-22910. 

The same amidation reaction was employed by Joshi et al. to covalently functionalize MWNTs with a specific peptide sequence, which specifically binds to the heptameric receptor-binding subunit of anthrax toxin.33 These nanotube-peptide conjugates were found to selectively destroy anthrax toxin with the reactive oxygen species generated by the nanotubes upon near-IR radiation.33... 

Colquhoun, A. and Schumacher, R.I., Gamma-linolenic acid and eicosapentaenoic acid induce modifications in mitochondrial metabohsm, reactive oxygen species generation, lipid peroxidation and apoptosis in Walker 256 rat carcinosarcoma cells, Biochim. Biophys. Acta, 1533, 207, 2001. 

Kushnareva Y, Murphy AN, Andreyev A (2002) Complex i-mediated reactive oxygen species generation Modulation by cytochrome c and nad(p)(+) oxidation-reduction state. Biochem J 368 545-553... 

The rates of NADPH consumption in liver by the various NADPH-dependent enzymes indicate that GSH reductase has by far the highest rate to detoxify the reactive oxygen species generated by the various sources. 

Figure 20.7. Mechanism of reactive oxygen species generation and detoxification.

Park, J., Gu, Y., Lee, Y., Yang, Z. and Lee, Y., 2004, Phosphatidic acid induces leaf cell death in Arabidopsis by activating the Rho-related small G protein GTPase-mediated pathway of reactive oxygen species generation. Plant Physiol. 134 129-136. 

Gunasekar, P.G., Sun, P., Kanthasamy, A.G., Borowitz, J.L., Isom, G.E. (1996). Cyanide-induced neurotoxicity involves nitric oxide and reactive oxygen species generation after A -methyl-D-aspartate receptor activation. J. Pharmacol. Exp. Ther. 111. 150-5. 

Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM, Schumacker PT. Reactive oxygen species generated at mitochondrial complex m stabilize hypoxia-inducible factor-lalpha during hypoxia a mechanism of O2 sensing. J. Biol. Chem. 2000 275 25130-25138. 

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