Multivariable identification

MacGregor, J.F., T. Kourti J. V. Kresta (1991), Multivariate identification a study of several methods , IFAC Advanced Control of Chemical Processes, Toulouse, Prance, 101-107. 

DOSY is a technique that may prove successful in the determination of additives in mixtures [279]. Using different field gradients it is possible to distinguish components in a mixture on the basis of their diffusion coefficients. Morris and Johnson [271] have developed diffusion-ordered 2D NMR experiments for the analysis of mixtures. PFG-NMR can thus be used to identify those components in a mixture that have similar (or overlapping) chemical shifts but different diffusional properties. Multivariate curve resolution (MCR) analysis of DOSY data allows generation of pure spectra of the individual components for identification. The pure spin-echo diffusion decays that are obtained for the individual components may be used to determine the diffusion coefficient/distribution [281]. Mixtures of molecules of very similar sizes can readily be analysed by DOSY. Diffusion-ordered spectroscopy [273,282], which does not require prior separation, is a viable competitor for techniques such as HPLC-NMR that are based on chemical separation. 

D. Wienke, W. van den Broek and L. Buydens, Identification of plastics among nonplastics in mixed waste hy remote sensing near-infrared imaging spectroscopy. 2. Multivariate rank analysis for rapid classification. Anal. Ghent., 67, 3760-3766 (1995). 

At-line PAT data nsed directly without conversion back to the original variables space - e.g., MVI (Mnltivariate Identification), MSPC (multivariate statistical process control). 

For effective control of crystallizers, multivariable controllers are required. In order to design such controllers, a model in state space representation is required. Therefore the population balance has to be transformed into a set of ordinary differential equations. Two transformation methods were reported in the literature. However, the first method is limited to MSNPR crystallizers with simple size dependent growth rate kinetics whereas the other method results in very high orders of the state space model which causes problems in the control system design. Therefore system identification, which can also be applied directly on experimental data without the intermediate step of calculating the kinetic parameters, is proposed. 

Van Den Hof, P.J.M. DUMSI-package for off line multivariable system identification Laboratory for Measurement and Control, Delft University of Technology, Delft, I989. 

Saz and Marina [148] published a comprehensive review on HPLC methods and their developments to characterize soybean proteins and to analyze soybean proteins in meals. In the case of soybean derived products, a number of papers dealing with cultivar identification [149,150], quantification of soybean proteins [151-154], detection of adulteration with bovine milk proteins [151,155-158], and characterization of commercial soybean products on the basis of their chromatographic protein profile [159,160] have been published in the last years. Other studies deal with the analysis of soybean proteins added to meat [161-165], dairy [151,165-167], and bakery products [156,163,168,169]. The same research group developed perfusion RP-HPLC methods for very rapid separation of maize proteins (3.4 min) and characterization of commercial maize products using multivariate analysis [170], and for the characterization of European and North American inbred and hybrid maize lines [171]. 

Three generic types of receptor model have been identified, chemical mass balance, multivariate, and microscopical identification. Each one has certain requirements for input data to provide a specified output. An approach which combines receptor and source models, source/ receptor model hybridization, has also been proposed, but it needs further study. 

In an attempt to provide this focus, forty-seven active receptor model users from government, university, consulting and industry met for 2 1/2 days in February 1980 it. They addressed the models and the information required to use them in six separate task forces 1) Chemical Element Balance Receptor Models, 2) Multivariate Receptor Models, 3) Microscopic Identification Receptor Models, 4) Field Study Design and Data Management, 5) Source Characterization, and 6) Analytical Methods. The objectives of these interrelated task forces were to ... 

Domenech A, Domenech-Carbo MT, Edwards HGM. (2007) Identification of earth pigments in severely damaged frescoes by applying multivariate chemometiic methods to solid state voltammetry. Electroanalysis 19 1890-1900. 

B. Tyler, Interpretation of TOF-SIMS images multivariate and univariate approaches to image de-noising, image segmentation and compound identification, Appl. Surf. Sci., 203-204, 2003, 825-831. 

For phenolics in fruit by-products such as apple seed, peel, cortex, and pomace, an HPLC method was also utilized. Apple waste is considered a potential source of specialty chemicals (58,62), and its quantitative polyphenol profile may be useful in apple cultivars for classification and identification. Chlorogenic acid and coumaroylquinic acids and phloridzin are known to be major phenolics in apple juice (53). However, in contrast to apple polyphenolics, HPLC with a 70% aqueous acetone extract of apple seeds showed that phloridzin alone accounts for ca. 75% of the total apple seed polyphenolics (62). Besides phloridzin, 13 other phenolics were identified by gradient HPLC/PDA on LiChrospher 100 RP-18 from apple seed (62). The HPLC technique was also able to provide polyphenol profiles in the peel and cortex of the apple to be used to characterize apple cultivars by multivariate statistical techniques (63). Phenolic compounds in the epidermis zone, parenchyma zone, core zone, and seeds of French cider apple varieties are also determined by HPLC (56). Three successive solvent extractions (hexane, methanol, aqueous acetone), binary HPLC gradient using (a) aqueous acetic acid, 2.5%, v/v, and (b) acetonitrile fol-... 

To base classification and possible identification upon the whole chemical information contained in the pollen, we used a multivariate method. For an... 

Conventional microbiological identification of isolates from patients can normally be obtained with a total turnaround time of 48-96 h. Ibelings et al. [106] and Maquelin et al. [46] developed alternatively a Raman spectroscopic approach for the identification of clinically relevant Candida species from smears and microcolonies in peritonitis patients taking at least overnight (smears) or about 6h (microcolonies). Hereby, a prediction accuracy of 90% was obtained for Raman spectroscopy in combination with multivariate statistical data analysis. 

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