Monkey Rhesus, Macaca mulatta

Arnold, DL, Bryce E, Karpinski K, et al. 1993. Toxicological consequences of Aroclor 1254 ingestion by female rhesus (Macaca mulatta) monkeys. Part IB. Prebreeding phase clinical and analytical laboratory findings. Pood Chem Toxicol 31(11) 811-824. 

Arnold DL, Nera EA, Stapley R, et al. 1996. Prevalence of endometriosis in Rhesus Macaca mulatta) monkeys ingesting PCB (Aroclor 1254) Review and evaluation. Pundamental and Applied Toxicology 31(l) 42-55. 

Tryphonas H, Hayward S, O Grady L, et al. 1989. Immunotoxicity studies of PCB (Aroclor 1254) in the adult rhesus (Macaca mulatta) monkey— preliminary report. Int J Immunopharmacol 11 199-206. 

Tryphonas H, Luster Ml, Schiffman G, et al. 1991b. Effect of chronic exposure of PCB (Aroclor 1254) on specific and low specific immune parameters in the rhesus (Macaca mulatta) monkey. Fund Appl Toxicol 16 773-786. 

It is difficult to assess the relationship of HEAR oils and other oils high in docosenoic acid content to the development of focal myocardial degenerative lesions in the monkey. In a recent study, a series of 312 hearts were selected at random from monkeys used in unrelated toxicological studies (Qureshi, 1979). The monkeys, which included squirrel (Saimiri sciureus) cynomolgus Macaca fascicularis), rhesus Macaca mulatta) and assam (Ma-caca assamensis) monkeys were of both sexes. Chronic interstitial myocarditis was found in 34% of the monkeys, approximately evenly distributed in males and females (Table IX). The lesions varied from slight necrosis to myocarditis with focal accumulation of lymphocytes, mononuclear cells, plasma cells, and some eosinophiles. Inflammation of the myocardium was distributed throughout the heart. These lesions, which occur frequently in primates, apparently are not related to bacterial, viral, or parasitic infections, but may be related to, and precipitated by, stress (Qureshi, 1979 Soto et al., 1964). 

Silverman, A. J., Antunes, J. L., Abrams, G. M., Nilaver, G., Thau, R., Robinson, J. A., Ferin, M., and Krey, L. C., 1982, The luteinizing hormone-releasing hormone pathways in rhesus, Macaca mulatta and pigtailed, Maccaca nemestrina monkeys, J. Comp. Neurol., 211 309. 

Pounds JG, Marlar RJ, Allen JR. 1978. Metabolism of lead-210 in juvenile and adult Rhesus monkeys Macaca mulatta. Bull Environ Contain Toxicol 19 684-691. 

As above, except dose is 50 pg Pb/kg BW Rhesus monkey, Macaca mulatta Blood lead 154 pg/L (vs. 35 pg/L in controls), declining to 109 pg/L at day 150 postadministration. At age 3 years, group showed impaired color discrimination. No overt signs of toxicity, normal blood chemistry (except lead), normal growth and development skills 21... 

Rhesus monkey, Macaca mulatta 0.5 mg/kg BW during days 20-30 of pregnancy Maternally toxic, and abortient 1... 

Sv Rhesus monkey, Macaca mulatta Permanent sterility, males 13... 

Higley, J.D., Thompson, W.W., Champoux, M., Goldman, D., Has-ert, M.F., Kraemer, G.W., et al. (1993). Paternal and maternal genetic and environmental contributions to cerebrospinal fluid monoamine metabolites in rhesus monkeys (macaca mulatta). Arch Gen Psychiatry 50 615-623. 

Lagarde D, Laurent J, Milhaud C, et al Behavioral effects induced by beta CCE in free or restrained rhesus monkeys (Macaca mulatta). Pharmacol Biochem Behav 35 713-719, 1990... 

Rhesus monkey, Macaca mulatta Infants given 0.5 mg Pg/kg diet for 4 weeks... 

Rhesus monkey, Macaca mulatta Females, single acute dose of 0.25-6.5 Gy, observed over a 17-year postexposure period... 

McConnell EE, Moore JA, Dalgard DW. 1978a. Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rhesus monkeys (Macaca mulatta) following a single oral dose. Toxicol Appl Pharmacol 43 175-187. 

Rier SE, Martin DC, Bowman RE, et al. 1993. Endometriosis in Rhesus monkeys (Macaca mulatta) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fund Appl Toxicol 21 433-441. 

Rhesus monkeys (Macaca mulatta) are another species used for DART evaluation [4], However, this species displays pronounced seasonality of reproductive activity for both sexes [13,14], In this primate, reproductive functions are entirely shut off or severely diminished for approximately half of the year. In environments with distinct seasons sexual activity and gonadal activity are present roughly throughout October until March, but this may vary substantially for individual animals. It is crucial to consider that the annual rhythmicity of reproductive cycles can persist over years in captivity and under indoor artificial light pattern conditions [15], Hence in indoor circumstances seasonality of reproduction may be uncoupled from the outdoor season, and eventually an animal may display periodic reproductive activation in unexpected months. 

Pal SB (1979) The pattern of urinary excretion of corticosteroids in Rhesus monkeys (Macaca mulatta). Endocrinology 73 359-62... 

Klonne, D.R., C.E.Ulrich, M.G.Riley, T.E.Hamm, Jr., K.T.Morgan, and C.S.Barrow. 1987. One-year inhalation toxicity study of chlorine in rhesus monkeys (Macaca mulatta). Fundam. Appl. Toxicol. 9(3) 557-572. 

Ecologically, macaques live in a great variety of habitats from tropical rainforests of southeast Asia, to the agricultural plains of northern India, the deserts of Rajasthan, the arid mountains of Pakistan and Afghanistan, and even temperate snow-capped mountains of Japan, northern China, Nepal, and Morocco. Several species are also conspicuous commensal inhabitants of villages, temples, towns, and cities in Asia, especially the rhesus monkey in India and Nepal, the Japanese monkey, and the crab-eating monkey of southeast Asia and Indonesia. One species alone, the rhesus monkey, Macaca mulatta, is both a close commensal associate of human populations in the crowded cities of India, and an inhabitant of cool pine forests in northern India. 

Regional variations in percutaneous absorption contribute to differences in the systemic availability of a drug depending on the site of topical application. The Rhesus monkey Macaca mulatta) could probably serve as an animal model for human skin regional variation.f ° ... 

Warren D, Cornelius C, Ford B. 1984. Liver function studies on Rhesus monkeys Macaca mulatta) following the administration of hydrazine sulfate. Vet Hum Toxicol 26 295-299. 

Altman NH, New AE, McConnell EE, et al. 1979. A spontaneous outbreak of polychlorinated biphenyl (PCB) toxicity in Rhesus monkeys macaca mulatta) Clinical observations. Lab Anim Sci 29(5) 661-665. 

Bowman JP, Sladek JR Jr (1973) Morphology of the inferior olivary complex of the rhesus monkey (Macaca mulatta). J. Comp. Neurol. 152, 299 -316. 

Robertson LT, Roman N (1989) Distribution of acetylcholinesterase in the granular layer of the cerebellum of the rhesus monkey (Macaca mulatta). Brain Behav. Evol, 34, 342-350. 

Bennett, J. S., K. A. Gossett, M. P. McCarthy, and E. D. Simpson. 1992. Effects of ketamine hydrochloride on serum biochemical and hematologic variables in Rhesus monkeys Macaca mulatta). Veterinary Clinical Pathology 21 15-18. 

Hendrickx, A. G., Teratologic evaluation of imipramine hydrochloride in bonnet (Macaca radiata) and rhesus monkeys (Macaca mulatta). Teratology, 1975, 111 219-222. 

Mattix ME, Hunt RE, Wilhelmsen CL, Johnson AJ, Baze WB. Aerosolized staphylococcal enterotoxin B-in-duced pulmonary lesions in rhesus monkeys (Macaca mulatta). Toxicol Pathol. 1995 23 262-268. 

Rhesus macaque, Macaca mulatta, 634, 643 Rhesus monkey, Macaca mulatta, 273, 599, 634, 640, 643, 722, 794, 805, 864, 884 Tamarin monkey, Saguinus fuscicollis, 233 Moose, Afces alces, 142, 465, 552, 704, 737... 

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