Liver function studies

Periodic laboratory tests (liver function studies) and ultrasound or radiologic examinations of the gallbladder may be scheduled by the primary health care provider. 

A9. Aronsen, K. F., Liver function studies during and after complete extraheptic biliary obstruction in the dog. Acta Chit. Scand. Suppl. No. 275, 54 and 76 (1961). 

The weight of evidence from in vivo and in vitro genetic toxicology tests, in vivo liver function studies, and the two-stage tumor promotion assay is adequate to conclude that chlordecone is a promotor rather than an initiator of carcinogenesis. While the evaluation of mirex in an in vivo tumor promoter... 

In humans, early symptoms of intoxication may include headache, dizziness, nausea, vomiting, malaise, and myoclonic jerks of the limbs clonic and tonic convulsions and sometimes coma follow and may occur without the premonitory symptoms. A suicidal person who ingested 25.6mg/kg developed convulsions within 20 minutes that persisted recurrently until large amounts of barbiturates had been administered. Hematuria and azotemia occurred the day after ingestion and continued for 18 days. Liver function studies were within normal limits except for an elevated icterus index an electroencephalogram revealed generalized cerebral dysrhythmia, which returned to normal after 5 months. ... 

L/Verft/ncf/on-Abnormal elevations of AST, ALT, LDH, bilirubin, and alkaline phosphatase have occurred, and are usually reversible on drug discontinuation. Perform periodic liver function studies and terminate therapy if abnormalities persist. 

Monitoring Perform baseline and periodic leukocyte and differential counts and liver function studies. Fever or sore throat may signal serious neutrophil depression discontinue therapy if there is evidence of pathological neutropenia. 

Hepatic effects Fatal and nonfatal liver disorders of an idiosyncratic or hypersensitivity type may occur. At the start of therapy, perform baseline liver function studies. If abnormalities exist, the potential for hepatotoxicity could be enhanced. 

Perform liver function studies at appropriate intervals during therapy. If such studies reveal abnormal values, generally discontinue therapy. Some laboratory values may return to normal with continued therapy others may not. 

Monitoring Determine baseline liver function studies and uric acid levels prior to therapy. Perform appropriate laboratory testing at periodic intervals and if any clinical signs or symptoms occur during therapy. 

Monitoring Monitor patients by hematologic, renal excretion, blood level, and liver function studies. 

CNS Bowel Dysfunction Bladder Dysfunction ar other Elevated liver function studies... 

Liver function studies and serum levels during treatment... 

Blood counts and liver function studies should be monitored during long-term therapy. The drug should not be given to patients with known hypersensitivity to other benzimidazole drugs or to those with cirrhosis. The safety of albendazole in pregnancy and in children younger than 2 years of age has not been established. 

LeWinn EB. Gynecomastia during digitalis therapy report of eight additional cases with liver-function studies. N Engl J Med 1953 248(8) 316-20. 

Warren D, Cornelius C, Ford B. 1984. Liver function studies on Rhesus monkeys Macaca mulatta) following the administration of hydrazine sulfate. Vet Hum Toxicol 26 295-299. 

A6. Allan, J. S., and Tyler, E. T., Biochemical finding in long-term oral contraceptive usage. I. Liver function studies. Fertility Sterility 18, 112-123 (1967). 

Hepatic Effects. Little information was available regarding hepatic effects in humans. Liver function studies and serum levels of hepatic enzymes have been found to be normal in occupationally exposed workers with chronic inhalation exposure to inorganic manganese (Mena et al. 1967). No information was available regarding oral exposure to inorganic manganese in humans. Animal studies (both inhalation and... 

Toxic manifestations include myelosuppression, GI symptoms, rashes, and abnormal liver function studies at standard (4 mg/rri ) doses. Depletion of normal T cells occurs at these doses, and neutropenic fever and opportunistic infections can occur. Immunosuppression may persist for several years after discontinuation of pentostatin therapy. At higher doses (10 mg/m ), major renal and neurological complications are encountered. The use of pentostatin in combination with fludarabine phosphate may result in severe or even fatal pulmonary toxicity. 

Fortunately, bed rest, rehydration, parenteral nutrition, and therapy directed at decreasing the production of toxins that result from bacterial degradation of nitrogenous substrates in the gut lumen (e.g., administration of lactulose, which reduces gut ammonia levels by a variety of mechanisms, the use of enemas and antibiotics to decrease the intestinal flora, a low-protein diet) prevented Percy Veere from progressing to the later stages of hepatic encephalopathy. As with most patients who survive an episode of fulminant hepatic failure, recovery to his previous state of health occurred over the next 3 months. Percy s liver function studies returned to normal, and a follow-up liver biopsy showed no histologic abnormalities. 

Previously reported (Cohen et, 1972) experimental in vitro guinea pig liver explant studies from this laboratory tend to support the suggestion that the parent hydrolysate compounds and selective amino acids may be responsible for the abnormal liver function studies in children being treated with parenteral nutrition. In these studies four amino acids (glycine, leucine, isoleucine, threonine) were shown to increase serum GPT activity in organ culture but the mechanism for this elevated activity could not be further defined. 

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