Ketamine hydrochloride

500 parts of water are added and the whole is allowed to stand for 24 hours at 5°C. The 1,2-diphenyl-4-(3 -oxobutyl)-3,5-dioxopyrazolidine which precipitates is fiitered off under suction and washed with 50% acetone. Meiting point from aicohol/water mixture 115.5°C to 116.5°C. Sometimes a crystal form is obtained which meitsat 127.5°C to 128.5°C. 

Pfister, R.and Hafliger, F. U.S. Patent 2,910,481 October 27,1959 assiged to Geigy Chemical Corp. 

Chemical Name 2-(o-chlorophenyl)-2-(methylamino)-cyclohexandne hydrochloride Common Name — 

Trade Name Manufacturer Country Year Introduced 

The 1-hydroxycyc(openty(-(o-ch(orophenyl)-ketone N-methylimine used as an intermediate is prepared as follows. To the Grignard reagent prepared from 119.0 g of cyclopentyl 

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Another injectable anesthetic widely used in feline and primate practice is ketamine hydrochloride [1867-66-9]. Ketamine, a derivative of phencychdine, can be chemically classified as a cyclohexamine and pharmacologically as a dissociative agent. Analgesia is produced along with a state that resembles anesthesia but in humans has been associated with hallucinations and confusion. For these reasons, ketamine is often combined with a tranquilizer. The product is safe when used in accordance with label directions, but the recovery period may be as long as 12—24 h. 

KETAMINE HYDROCHLORIDE INJECTION 10QMG/ML 5ML VIAL 10 VIALS/PG 6505011533733 PG 175,45 ... 

Ketamine hydrochloride (100 mg/mL solution dose of 10 mg/kg), given by intramuscular injection. 

The mother is sedated by intramuscular injection of 10 mg/kg Ketamine hydrochloride (100 mg/mL solution) in combination with 0.06 mg/kg Medetomidine (1.0 mg/mL Medetomidine hydrochloride). 

Beings in the Bonnet realm sometimes have blank eye sockets. This image is also occasionally reported by people who have used the hallucinogen Special K (ketamine hydrochloride). One person e-mailed me to tell me that, while under the influence of Special K, everything was normal except that people in the room suddenly had no eye sockets, just black voids, and he saw light being sucked into the void from around the periphery of the eyeballs. Ketamine has also been associated with feelings of ego loss, out-of-body experiences, and near-death experiences. 

Various general anesthetics ketamine hydrochloride midazolam hydrochloride propofol... 

DRUG CLASSIFICATIONS Schedule I, hallucinogen OFFICIAL NAMES Ketamine hydrochloride (brand names include Ketaject, Ketaset and Ketalar)... 

OFFICIAL NAMES Ketamine hydrochloride, Ketaject, Ketaset, and Ketalar. 

The chemical composition of ketamine hydrochloride is C13H16CINO. The formal name for the chemical is 2-(2-chlorophenyl)-(methylamino)-cyclohexanone hydrochloride. The chemical stmcture and effects of ketamine are similar to those of PCP, which it was developed to replace, but ketamine is much less potent and its effects are of much shorter duration. 

Ketamine hydrochloride (Ketalar) is primarily used as an animal tranquilizer. When humans use the drug in a nonmedical setting, ketamine can cause hallucinations, amnesia, and dissociation. It is often used with other drugs such as ecstasy, heroin, or cocaine. Due to widespread abuse by young people, the DEA classified this drug as a Schedule III controlled substance in 1999. 

All of the neuroleptics are consumed in their pure form and are rarely abused. Most of the sedative-hypnotics of abuse are diverted from legitimate sources and remain in their pure form. However, occasionally powdered forms of illegal drugs (such as ketamine hydrochloride), which are often manufactured in clandestine laboratories, are mixed with tobacco, marijuana, or other drugs. 

H. Y. Aboul-Enein and M. R. Islam, Enantiomeric separation of ketamine hydrochloride in pharmaceutical formulations and human serum by chiral liquid chromatography, J. Liquid Chromatogr., 75 3285(1992). 

In the years intervening since the last edition, ketamine hydrochloride, which appears in Chapter Ten among "Contrasting Profiles," has come to be regarded by many of those involved in this area of study as a unique, significant, and bona fide—if somewhat hazardous—psychedelic. Therefore new front matter of additional information about this compound appears in this volume. 

Dogs are anaesthetized with a combination of Rompun (xylazine hydrochloride, 1 ml/10 kg, i.v.) and Ketavet (ketamine hydrochloride, 0.7 ml/10 kg, i.v.) after premedication with Temgesic (Buprenorphin, 0.2mg/kg i.m.) and ventilated with 66% N2O and 33 % O2 and 1 % Isofluorane. All procedures are performed under aseptic conditions using sterilized equipment. 

Ketamine, more commonly known on the street as Special K and to the scientist as ketamine hydrochloride, is a unique drug with a combination of pharmacological effects. Although it is primarily used by veterinarians as an animal tranquilizer, it is available for limited uses in humans. Chemically, it is similar to phencyclidine (PCP or angel dust), a Schedule II drug that was the first of a new class of general anesthetics called dissociative anesthetics. As the name implies, dissociative anesthetics produce in patients a feeling of detachment and disconnection from pain and the environment. 

In 1962, chemists at Parke-Davis labs who were searching for a replacement for phencyclidine synthesized ketamine hydrochloride. In 1965, scientists learned that ketamine was a useful anesthetic. Marketed under the brand name Ketalar , it was a promising anesthetic because it suppressed breathing much less than most other available anesthetics did. Ketamine, like PCP, produces minimal cardiac and respiratory effects, and it wears off soon after administration.50... 

Smith, K. M., L. L. Larive, and F. Romanelli. Club Drugs Methylene-Dioxymethamphetamine, Flunitrazepam, Ketamine Hydrochloride and Gamma Hydroxybutyrate. American Journal of Health System Pharmacy 59 (2002) 1067-1076. 

Smith KM, Larive LL, Romanelli F. Club drugs methylenedioxymethamphetamine, flunitrazepam, ketamine hydrochloride, and gamma-hydroxybutyrate. Am J Health Syst Pharm 2002 59(ll) 1067-76. 

SYNS CI 581 CL369 CN-52,372-2 KETAJECT KETAL. R KETAMINE KETAMINE HYDROCHLORIDE KETANEST KETASET KETAVET KETOLAR VETALAR... 

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