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Molecular protein

In molecular pharmacology research an indirect proof of a structural model is possible by functional examinations, e.g., by molecular biological experiments. Well-selected site directed mutagenesis and their functional characterization allows confirmation or rejection of a molecular protein model. The process is organized as an iterative procedure, where the biological answer of suggested mutations is used to refine the model. The iteration continues until the model... [Pg.779]

A major contribution of the free-radical scavenging activity in blood plasma is attributable to the macro-molecular proteins (Wayner et al., 1985) of which albumin is a primary component and trapping agertt (Holt et al., 1984). Serum sulphydryl levels, primarily albumin-related, are decreased in subjects with rheumatoid complicated coalworkers pneumoconiosis, indicative of exacerbated inflammatory R.OM production (Thomas and Evans, 1975). Experimental asbestos inhalation in rats leads to an adaptive but evidendy insufficient response by an increase in endogenous antioxidant enzymes (Janssen etal., 1990). Protection of the vascular endothelium against iron-mediated ROM generation and injury is afforded by the iron sequestiant protein ferritin (Balia et al., 1992). [Pg.254]

Latrodectus - widow spiders (back, brown red-legged spider) Bite - neurotoxin -large molecular proteins Localized pain, sweating, muscle cramps, decreased blood pressure... [Pg.160]

Table 11 demonstrates, as in the previous case, the increased amount of immobilized heparin when the spacer was used the anticoagulant activity of immobilized heparin being around 10% of the initial heparin activity. The reason for the observed loss of initial activity is probably the inaccessibility of the immobilized heparin for high-molecular proteins (thrombin with a molecular mass of 34000 and antithrombin III with a molecular mass of 65 000) as the permeability of the grafted gels, whose water content was only 55 %, [Pg.113]

Found that the anionic form of the Coomassie dye reacts primarily with arginine residues within the macro molecular protein. Coomassie dye reacts to a lesser extent with other basic amino acid residues (His, Lys) and aromatic residues (Try, Tyr, Phe) present in macromolecularproteins, but not with the free amino acids. Dye binding is attributed to van der Waals forces and hydrophobic interactions. The interference seen with bases, detergents, and other compounds can be explained by their effects upon the equilibrium between the three dye forms (cationic, neutral, anionic). [Pg.103]

Nutrient medium is supplemented with 5% fetal bovine serum. Low molecular weight serum proteins diffuse across the dialysis membrane between the nutrient and production modules. A reservoir of low molecular proteins is required in the nutrient module to maintain the equilibrium for hybridoma growth and survival. Accumulation of foam in the nutrient module can be a problem. To counteract foaming, do not exceed a concentration of 5% FBS in the nutrient module and add AntiFOAMa antifoaming agent. Do not fill the nutrient module with more than 400 mL of nutrient medium. An air space is required within the module to ensure successful hybridoma growth. [Pg.203]

The low molecular protein, the antibiotic nisin, was successfully concentrated in industrial scale from a culture liquid in a high expansion ratio foam, stabilised with the foaming agent Tween-80. In the absence of a special foaming agent no stable foam was produced from the culture liquid. Nisin could be extracted by adding Tween-80, though the... [Pg.688]

The concentration of vitamin A is raised in chronic renal insufficiency, because reduced filtration of low molecular proteins results in increased concentrations of retinol binding protein. A retrospective evaluation of 18 liver biopsies in 71 patients on hemodialysis taking therapeutic doses of vitamin A showed hyperplasia of stellate cells in 7, but no evidence of fibrosis (115). [Pg.3664]

The production method for low molecular protein hydrolysates has been described earlier W. A controlled batch hydrolysis using the pH-stat is performed, and the protein hydrolysate is then recovered by e.g. solids separation. Hyperfiltration may be used for concentration and/or desalination. Instead of using the controlled batch hydrolysis and solids separation processes, the separation of peptides may be performed from an enzyme-substrate reaction mixture under continuous ultrafiltration in a so-called membrane reactor. [Pg.134]

LOW MOLECULAR PROTEIN HYDRO-LYZATES - - CONCENTRATION AND/OR DESALINATION BY HF... [Pg.135]

Leokband D 1995 The surfaoe foroe apparatus—a tool for probing molecular protein interactions Nature 376 617-18... [Pg.1747]

Vedani A 1988. YETI An Interactive Molecular Mechanics Program for Small-Molecular Protein Complexes Journal of Computational Chemistry 9 269-280. [Pg.252]

In our study, the 60 C/EG-core complex contained the same level of 5 kDa polypeptide as that of PS 1-200 (Table 1), suggesting that the 5 kDa polypeptide is closely associated with the high molecular weight polypeptides. The content of this low molecular protein decreased when the core complex was isolated from 70 C/EG-treated particles lacking ail FX (Table 1). [Pg.1530]

It appears from the autoradiograms that oligomeric and monomeric forms of LHCII (LHCP I and LHCP III beinds) were the most heavily phosphorylated for all variants. A slight labelling was also observed in the CPa band (PS2 reaction centers) and low-molecular proteins that contained no chlorophyll. The incorporation of into LHC II proteins... [Pg.1750]


See other pages where Molecular protein is mentioned: [Pg.270]    [Pg.200]    [Pg.162]    [Pg.194]    [Pg.554]    [Pg.340]    [Pg.42]    [Pg.162]    [Pg.160]    [Pg.210]    [Pg.383]    [Pg.93]    [Pg.328]    [Pg.1138]    [Pg.263]    [Pg.554]    [Pg.49]    [Pg.134]    [Pg.144]    [Pg.152]    [Pg.294]    [Pg.25]    [Pg.1190]    [Pg.802]    [Pg.154]    [Pg.227]    [Pg.389]    [Pg.963]    [Pg.81]    [Pg.220]    [Pg.20]    [Pg.185]   
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Aggregate structure, protein molecular

Antibody molecular recognition between protein

Bacterial Protein Biomarker Discovery A Focused Approach to Developing Molecular-Based Identification Systems

Bio-molecular simulation protein force fields

Bio-molecular simulation protein-ligand interactions

Capillary sieving electrophoresis protein molecular weight determination

Coherence transfer in high molecular weight proteins

Cytosolic protein folding molecular chaperones

ET via Molecular-Recognition Process on Protein Surface

Folded proteins, molecular

Folded proteins, molecular dimension

For Proteins of Higher Molecular Weight

Heat shock proteins molecular chaperone role

Heat shock proteins, molecular targets

Helical proteins, molecular model

High-molecular weight blood proteins

Human Insulin For Proteins of Higher Molecular Weight

Ligand-protein binding molecular dynamics

Low Molecular Weight GTP-Binding Proteins

Low molecular weight proteins

Low-molecular-weight G-proteins

Lyophilized protein formulations, molecular

Lyophilized protein formulations, molecular mobility

Mass spectrometry determining protein molecular weight

Membrane channel protein, function molecular model

Membrane-bound proteins molecular modeling

Minimum molecular weight ratio proteins

Model proteins molecular structure

Molecular Basis of Protein-Carbohydrate Interactions

Molecular Interactions of LLCs with Proteins and Nucleotides

Molecular Machines for Protein Degradation

Molecular Mechanisms for the Interaction of Regulatory Proteins with Chromosomal DNA

Molecular Recognition in Biology: Models for Analysis of Protein-Ligand

Molecular biological techniques, protein

Molecular biology protein synthesis

Molecular chaperones heat-shock proteins

Molecular complexes proteins

Molecular dynamic simulations protein flexibility

Molecular dynamics , protein structure

Molecular dynamics of polypeptides and proteins

Molecular dynamics protein folding

Molecular dynamics protein hydration

Molecular dynamics simulation proteins

Molecular genetics protein synthesis

Molecular machines protein-based polymer

Molecular mass measurement of proteins

Molecular mass of proteins

Molecular mimicry, viruses proteins

Molecular modeling MoFe-protein

Molecular modeling protein force fields

Molecular modeling protein structure prediction

Molecular modeling protein-ligand interactions

Molecular modelling molecules proteins quantum mechanics

Molecular motors Motor proteins

Molecular orbitals protein chromophores

Molecular protein-ligand

Molecular protein-ligand shape similarity

Molecular recombinant proteins

Molecular shape of proteins primary, secondary and tertiary structures

Molecular weight native protein

Molecular weight of proteins

Molecular weight proteins and

Molecular weights storage proteins

Molecularly imprinted protein matrices for catalysis

Molecularly imprinted protein matrices for recognition and separation

Motors, molecular protein, actin-binding

Peptides/proteins molecular mass determination

Plasma proteins molecular dimensions

Plugging Nanomaterials into Proteins - Molecular Wires

Pressure-Induced Structural Transition of Protein and Molecular Recognition

Prion protein molecular basis

Protein adsorption molecular models

Protein affinity chromatography molecular interaction

Protein affinity chromatography molecular properties

Protein antigens molecular size

Protein antigens molecular weight

Protein chromatography molecular weight determination

Protein dynamics molecular modelling

Protein folding molecular chaperones

Protein hydration layer molecular structure

Protein interaction points (GRID molecular

Protein molecular assembly, aggregate

Protein molecular chaperone role

Protein molecular evolution

Protein molecular evolution amino acid substitution

Protein molecular evolution control

Protein molecular evolution description

Protein molecular evolution function

Protein molecular evolution potentials

Protein molecular evolution protocols

Protein molecular evolution searching space

Protein molecular evolution shuffling

Protein molecular evolution space

Protein molecular evolution structures

Protein molecular mass determination

Protein molecular masses

Protein molecular models

Protein molecular weights, brush border

Protein sequencing molecular biology

Protein! s) molecular weight

Protein, molecular imaging

Protein-Ligand Interactions: From Molecular Recognition to Drug Design

Protein-based molecularly imprinted

Protein-based molecularly imprinted preparation

Protein-ligand complexes, molecular

Protein-ligand complexes, molecular recognition

Protein-surface interactions molecular simulation

Proteins and their high molecular weight fragments

Proteins molecular constants

Proteins molecular dynamics

Proteins molecular modelling

Proteins molecular probe/ dynamics

Proteins molecular properties

Proteins molecular self-assembly

Proteins molecular shape

Proteins molecular size

Proteins molecular stabilization

Proteins molecular structure

Proteins molecular weight determination

Proteins molecular weights

Proteins single molecular protein folding

Proteins single-force molecular interaction

Proteins tertiary structure, molecular interaction

Proteins) molecular biology

Reduced proteins, molecular weights

Renal Delivery Using Macromolecular Carriers The Low-Molecular Weight Protein Approach

SCP2 with other low molecular weight proteins

Separation of Peptides and Proteins by Molecular Sieving

Simulation of protein molecular dynamics

Solving Protein Structures Using Restrained Molecular Dynamics and Simulated Annealing

Steroid Molecular Structure, Protein Interaction and Biological Function

Stress protein molecular chaperones

Structure-based computational models of ligand-protein binding dynamics and molecular docking

The central dogma of molecular biology and protein synthesis

Time scales molecular dynamics simulations, protein

Transport protein, molecular architecture

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