Prion protein molecular basis

Burkhard P, Stetefeld J, Strelkov SV Coiled coils A highly versatile protein folding motif. Trends Cell Biol 2001 11 82. Collinge J Prion diseases of humans and animals Their causes and molecular basis. Annu RevNeurosci 2001 24 519. 

Several NMR studies were carried out to gain insight into the molecular basis for the conversion of the PrP " into the pathogenic conformer, PrP . They mainly involve the study of prion-derived peptides believed to be essential for prion propagation, although other studies also include the investigation of the whole prion protein ° and prion mutants. 

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