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Liver biopsies

Polysaccharide Analysis of Liver Biopsy Specimens Obtained at Laparotomy, D. J. Tipper, M. Stacey, and S. A. Barker, Clin. Chim. Acta, 4 (1959) 861-866. [Pg.33]

There is very little data on ROM production in haemochromatosis in humans. Increases in thiobarbituric acid reactants in plasma were associated with increases in non-transferrin-bound free iron. However, other indices of lipid peroxidation were no different from controls (Peters eta/., 1985). There are no studies of in vivo lipid peroxidation in humans. It is also of interest that levels of antioxidant defences in liver biopsies from patients with haemochromatosis are normal (Selden et /., 1980). [Pg.157]

Non-compressible vascular puncture (such as a recent liver biopsy or carotid artery puncture)... [Pg.96]

Ultrasound examination is used routinely to evaluate cirrhosis a small, nodular liver with increased echogenicity is consistent with cirrhosis. Liver biopsy is the only way to diagnose cirrhosis definitively, but it is often deferred in lieu of a... [Pg.329]

Diagnosing viral hepatitis may be difficult because most infected individuals are asymptomatic. Because symptoms cannot identify the specific type of hepatitis, laboratory serologies must be obtained (Table 21-2). In addition, liver function tests may be obtained to assess the extent of cholestatic and hepatocellular injury. However, the definitive test to determine the amount of damage and inflammation of hepatic cells is a liver biopsy. [Pg.348]

Liver biopsy Mild inflammation and minimal fibrosis (grade 1, stage 1 disease) that is consistent with chronic hepatitis C... [Pg.350]

General outcomes for treating hepatitis are to (1) prevent the spread of the disease (2) prevent and treat symptoms (3) suppress viral replication (4) normalize hepatic aminotransferases (5) improve histology on liver biopsy and (6) decrease morbidity and mortality by preventing cirrhosis, hepatocellular carcinoma, and ESLD. [Pg.350]

Review the liver biopsy report (if available) to determine the severity of liver damage and need for chronic hepatitis B or C treatment. [Pg.358]

Methotrexate Monitor complete blood cell count and liver function tests at baseline and regularly, and consider liver biopsy prior to treatment and at a cumulative dose of 1.5 g. If available, monitor PIIINP at least three times yearly. [Pg.957]

Herbal remedies that have been reported to be he-patotoxic include chaparral (Larrea tridentata), germander (Teucrium chamaedrys), and life root (Senecio aureus) [18]. Cases reported patients developing jaundice, fatigue, pruritus, markedly elevated serum liver enzyme levels, severe cholestasis, hepatitis, and hepatocellular injury or necrosis documented by serial liver biopsies [19-21]. Signs and symptoms may occur as early as 3 weeks to as late as 7 months following ingestion [20,21]. [Pg.735]

Alderman S, Kailas S, Goldfarb S, et al. Cholestatic hepatitis after ingestion of chaparral leaf confirmation by endoscopic retrograde cholangiopancreatography and liver biopsy. J Clin Gastro 19(3) 242-247, 1994. [Pg.744]

The practicing clinician has a number of different tests available to aid in the evaluation of patients with suspected hepatitis C. These include measurement of alanine aminotransferase (ALT) levels, liver biopsy, serological tests (ELISA and recombinant immunoblot assay), and molecular methods for detection and quantitation of HCV RNA. [Pg.220]

Toxicities are GI (stomatitis, diarrhea, nausea, vomiting), hematologic (thrombocytopenia, leukopenia), pulmonary (fibrosis, pneumonitis), and hepatic (elevated enzymes, rare cirrhosis). Concomitant folic acid may reduce some adverse effects without loss of efficacy. Liver injury tests (aspartate aminotransferase or alanine aminotransferase) should be monitored periodically, but a liver biopsy is recommended during therapy only in patients with persistently elevated hepatic enzymes. MTX is teratogenic, and patients should use contraception and discontinue the drug if conception is planned. [Pg.50]

Liver biopsy plays a central role in the diagnosis and staging of liver disease. [Pg.255]

Liver biopsies for pathologic classification as chronic persistent hepatitis, chronic active hepatitis, or cirrhosis. [Pg.289]

Reese, J.A. and Byard, J.L. (1981). Isolation and culture of adult hepatocytes from liver biopsies. In Vitro 17 935-940. [Pg.686]

Vulnerability of the liver to injury necessitates routine evaluation of hepatic function in patients and asymptomatic individuals to avert or control adverse clinical conditions. Thus, a plethora of methods has been developed for the diagnosis of liver diseases and dysfunctions. One such method uses physical palpation to determine alterations or changes in the orientation of the liver, which provides valuable information about the organ status but the quality of information is subjective and imprecise [3]. Another common method for the diagnosis of more serious hepatic injuries involves liver biopsies coupled with biochemical tests to determine the extent of liver injury and prognosis [4-7]. However, in acute and some chronic hepatic disorders, dynamic and continuous hepatic function monitoring would be advantageous. [Pg.35]

Perform liver function tests on all patients during therapy with nicotinic acid. Monitor serum transaminase levels, including ALT and AST, before treatment begins, every 6 to 12 weeks for the first year, and periodically thereafter (at approximately 6-month intervals). Discontinue the drug if the transaminase levels show evidence of progression, particularly if they rise to 3 times the upper limit of normal and are persistent or if they are associated with symptoms of nausea, fever, or malaise. Consider liver biopsy if elevations persist beyond discontinuation. [Pg.632]

Monitoring Periodic monitoring for toxicity, including CBC with differential and platelet counts, and liver and renal function testing is mandatory. Periodic liver biopsies may be indicated in some situations. Monitor patients at increased risk for impaired methotrexate elimination (eg, renal dysfunction, pleural effusions, ascites) more frequently (see Precautions). [Pg.1969]

Liver Methotrexate causes hepatotoxicity, fibrosis, and cirrhosis, but generally only after prolonged use. Acutely, liver enzyme elevations are frequent, usually transient and asymptomatic, and also do not appear predictive of subsequent hepatic disease. Liver biopsy after sustained use often shows histologic changes, and fibrosis and cirrhosis have occurred these latter lesions often are not preceded by symptoms or abnormal liver function tests (see Precautions). For this reason, periodic liver biopsies are usually recommended for psoriatic patients who are under long-term treatment. Persistent abnormalities in liver function tests may precede appearance of fibrosis or cirrhosis in the RA population. [Pg.1969]

Psoriasis The usual recommendation is to obtain a liver biopsy at 1) pretherapy or shortly after initiation of therapy (2 to 4 months), 2) a total cumulative dose of 1.5 g, and 3) after each additional 1 to 1.5 g. Moderate fibrosis or any cirrhosis normally leads to discontinuation of the drug mild fibrosis normally suggests a repeat biopsy in 6 months. [Pg.1974]

Haemochomatosis should be treated with venesection, initially of 500 ml weekly and guided by serial serum ferritin levels and liver biopsy to assess residual iron stores. [Pg.633]


See other pages where Liver biopsies is mentioned: [Pg.42]    [Pg.43]    [Pg.197]    [Pg.154]    [Pg.155]    [Pg.356]    [Pg.955]    [Pg.1267]    [Pg.1455]    [Pg.222]    [Pg.263]    [Pg.313]    [Pg.774]    [Pg.291]    [Pg.22]    [Pg.24]    [Pg.82]    [Pg.98]    [Pg.204]    [Pg.109]    [Pg.267]    [Pg.474]    [Pg.474]    [Pg.253]    [Pg.276]    [Pg.276]    [Pg.277]    [Pg.232]   
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See also in sourсe #XX -- [ Pg.472 ]

See also in sourсe #XX -- [ Pg.653 ]

See also in sourсe #XX -- [ Pg.613 ]

See also in sourсe #XX -- [ Pg.221 , Pg.334 ]




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