Molecular biology protein synthesis

The most dramatic advances, without doubt, have been in protein biochemistry. The genetic basis of lipoprotein disorders is being probed with the tools of molecular biology, proteins concerned with lipoprotein metabolism are being characterized with structural and physiological studies, lipoprotein receptors are being fully characterized, and competitive inhibitors of the rate-limiting enzyme for cholesterol synthesis, HMG-CoA reductase, have been produced. 

Lin, C.Y. Key, J.L. (1967). Dissociation and reassembly of polyribosomes in relation to protein synthesis in the soybean root. Journal of Molecular Biology, 26, 237-47. 

In contrast to the biopharmaceuticals discussed thus far (recombinant proteins and gene therapy products), antisense oligonucleotides are manufactured by direct chemical synthesis. Organic synthetic pathways have been developed, optimized and commercialized for some time, as oligonucleotides are widely used reagents in molecular biology. They are required as primers, probes and for the purposes of site-directed mutagenesis. 

Synthesis of Fluorescent Functional Ras-Proteins by a Combined Organic Synthesis and Molecular Biology... 

The central dogma of molecular biology and protein synthesis... 

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