Protein adsorption molecular models

Kondo A and FllgashItanI K 1992 Adsorption of model proteins with wide variation In molecular properties on colloidal particles J. Colloid Interfaoe Sc/. 150 344-51... 

Fig. 4.4 Pore-filling models for protein adsorption in a mesopore channel (a) separated single-molecularadsorption (b) separated double-molecular adsorption (c) separated triple-molecular adsorption (d) interdigitated triple-molecular adsorption where adjacent layers are interdigitated by 1/4 of the protein diameter through changing the relative orientation. Adapted from [37],...

Due to the fact that protein adsorption in fluidized beds is accomplished by binding of macromolecules to the internal surface of porous particles, the primary mass transport limitations found in packed beds of porous matrices remain valid. Protein transport takes place from the bulk fluid to the outer adsorbent surface commonly described by a film diffusion model, and within the pores to the internal surface known as pore diffusion. The diffusion coefficient D of proteins may be estimated by the semi-empirical correlation of Poison [65] from the absolute temperature T, the solution viscosity rj, and the molecular weight of the protein MA as denoted in Eq. (16). 

Protein function at solid-liquid interfaces holds a structural and a dynamic perspective [31]. The structural perspective addresses macroscopic adsorption, molecular interactions between the protein and the surface, collective interactions between the individual adsorbed protein molecules, and changes in the conformational and hydration states of the protein molecules induced by these physical interactions. Interactions caused by protein adsorption are mostly non-covalent but strong enough to cause drastic functional transformations. All these features are, moreover, affected by the double layer and the electrode potential at electrochemical interfaces. Factors that determine protein adsorption patterns have been discussed in detail recently, both in the broad context of solute proteins at solid surfaces [31], and in specific contexts of interfacial metalloprotein electrochemistry [34]. Some important elements that can also be modelled in suitable detail would be ... 

Achaerandio, I., Pachova, V., Guell, C., Lopez, F. (2001). Protein adsorption by bentonite in a white wine model solution Effect of protein molecular weight and ethanol concentration. Am. J. Enol. Vitic., 52,122-126... 

A review of various theoretical (molecular-statistical, scaling and thermodynamic) models which describe the adsorption of proteins at liquid/fluid interface was presented in [86]. Here the thermodynamic models derived to describe the protein adsorption are discussed briefly. The adsorption isotherm (2.27), and also the equation of state (2.26) accounting for the... 

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