Molecular chaperones cytosolic protein folding

Hartl PU, Hayer-Hartl M. Molecular chaperones in the cytosol from nascent chain to folded protein. Science 2002 295 1852— 1858. 

Cells have evolved mechanisms to prevent aggregation. Molecular chaperons like HSP 90 or HSP 70 bind non-native protein conformations or aggregation-prone folded intermediates from the cytosol, thereby reducing the likelihood of aggregate formation [35]. 

---