Proteins molecular biology

Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., and Walters, P. (2002) The Shape and Structure of Proteins, Molecular Biology of the Cell, 4th edn. Garland Science, New York and London. 

Rajagopal, A. and Simon, S.M. (2003) Suhcellular localization and activity of multidrug resistance proteins. Molecular Biology of the Cell, 14, 3389—3399. 

Michishita, E., Park, J.Y., Bumeskis, J.M., Barrett, J.C. and Horikawa, I. (2005) Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Molecular Biology of the Cell, 16, 4623 35. 

Mackiewicz, A., I. Kushner, and H. Baumann, eds. 1993. Acute phase proteins Molecular biology, biochemistry and clinical applications. Boca Raton, FL CRC Press. 

The modem era of biochemistry and molecular biology has been shaped not least by the isolation and characterization of individual molecules. Recently, however, more and more polyfunctional macromolecular complexes are being discovered, including nonrandomly codistributed membrane-bound proteins [41], These are made up of several individual proteins, which can assemble spontaneously, possibly in the presence of a lipid membrane or an element of the cytoskeleton [42] which are themselves supramolecular complexes. Some of these complexes, e.g. snail haemocyanin [4o], are merely assembled from a very large number of identical subunits vimses are much larger and more elaborate and we are still some way from understanding the processes controlling the assembly of the wonderfully intricate and beautiful stmctures responsible for the iridescent colours of butterflies and moths [44]. 

This argument was pointed out almost 30 years ago by Benzinger [49], in a paper which referred to some still earlier work of his, and yet its implications, even more pertinent today given tire wider use of calorimetry in molecular biology, still appear to be largely ignored, an exception being Weber s work on tire association entlialpy of protein subunits [50]. 

Lee B and F M liichards 1971. The Interpretation of Protein Structures Estimation of Static Accessibil ity. Journal of Molecular Biology 55 379-400. 

Richmond T J 1984. Solvent Accessible Surface Area and Excluded Volume in Proteins. Journal oj Molecular Biology 178 63-88. 

Mian, K Sjolander and D Haussler 1994. Hidden Markov Models in Computational Biology. Applications to Protein Modelling. Journal of Molecular Biology 235 1501-1531). 

Alonso D O V and V Daggett 1995. Molecular Dynamics Simulations of Protein Unfolding and Limited Refolding Characterisation of Partially Unfolded States of Ubiquitm in 60% Methanol and in Water. Journal of Molecular Biology 247 501-520. 

Bernstein F C, T F Koetzle, G J B Williams, E Meyer, M D Bryce, J R Rogers, O Kennard, T Shikanouchi and M Tasumi 1977. The Protein Data Bank A Computer-Based Archival File for Macromolecular Structures. Journal of Molecular Biology 112 535-542. 

Dunbrack R L Jr and M Karplus 1993. Backbone-dependent Rotamer Library for Proteins. Applic to Side-chain Prediction. Journal of Molecular Biology 230 543-574. 

Hohn L and C Sander 1993. Protein Structure Comparison by Alignment of Distance Matrices. Joun Molecular Biology 233 123-138. 

Koppensteiner W A, P Lackner, M Wiederstein and M J Sippl 2000. Characterization of Novel Proteins Based on Known Protein Structures. Journal of Molecular Biology 296 1139-1152. 

Levitt M 1976. A Simplified Representation of Protein Conformations for Rapid Simulation of Protein Folding. Journal of Molecular Biology 104 59-107. 

Levitt M1992. Accurate Modeling of Protein Conformation by Automatic Segment Matching. Journal of Molecular Biology 226 507-533. 

Murzin A G, S E Brenner, T Hubbard and C Chothia 1995. SCOP A Structural Classification of Proteins Database for the Investigation of Sequences and Structures. Journal of Molecular Biology 247 536-540. 

Needleman S B and C D Wunsch 1970. A General Method Applicable to the Search for Similarities in the Amino Acid Sequences of Two Proteins. Journal of Molecular Biology 48 443-453. 

Nlng Q and T J Sejnowsld 1988. Predicting the Secondary Structure of Globular Proteins Using Neural Network Models. Journal of Molecular Biology 202 865-888. 

Oiengo C A and W R Taylor 1993. A Local Alignment Method for Protein Structure Motifs. ]ourr Molecular Biology 233 488-497. 

Ortiz A R, A Kolinski and J Skolnick 1998. Fold Assembly of Small Proteins Using Monte C Simulations Driven by Restraints Derived from Multiple Sequence Alignments. Jourru Molecular Biology 277 419-446. 

Rost B and C Sander 1993. Prediction of Protein Secondary Structure at Better than 70% Accurt journal of Molecular Biology 232 584-599. 

Sali A and T L Blundell 1993. Comparative Protein Modelling by Satisfaction of Spatial Restraii journal of Molecular Biology 234 779-815. 

Sali A, E Shakhnovich and M Karplus 1994b. PCinetics of Protein Folding. A Lattice Model Study of Requirements for Folding to the Native State, journal of Molecular Biology 235 1614-1636. 

Tiers N L, W D Carlson and M Karplus 1987 Analysis of Side-Chain Orientations in Homologous Proteins. Journal of Molecular Biology 196 175-198. 

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