High-molecular weight blood proteins

Fibrinogen. Serum protein, together with the mechanism of hemo-coagulation, is present in normal CSF only in trace concentrations, probably due to its high molecular weight. An increase in CSF concentrations is always connected with severe damage of the blood-CSF barrier or mechanical obstruction in the... 

Albumin is of great importance in animal physiology in mail it constitutes about 50% of the plasma proteins (blood) and is responsible to a great extent for tile maintenance of osmotic equilibrium in the blood. The high molecular weight (68,000) of the albumin molecule prevents its excretion in the urine the appearance of albumin may indicate kidney damage. 

Immunoadsorption, an advanced therapeutic modality, focuses on detoxification of patient blood rich in high-molecular-weight pathogenic substances, mostly abnormal autoantibodies such as rheumatoid factors in rheumatoid arthritis (RA) and anti-DNA autoantibodies in systemic lupus erythematosus (SLE). Detoxification of these pathogens will be accomplished through extracorporeal perfusion of the patient plasma or whole blood over an affinity column made of immunoadsorbents. These adsorbents perform their function through the same mechanism as conventional affinity adsorption, where proteins in the liquid phase are adsorbed on the specific ligands immobilized onto an insoluble support. 

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