Microencapsulation drug delivery

Biodegradable film (145), foam-molding compositions (eg, sponges) (146), tobacco substitutes (147), and microencapsulated drug-delivery systems (148) are potentially new and useful applications for cellulose acetate esters. 

Drug delivery systems, cell microencapsulation Drug delivery systems, cell microencapsulation... 

Ribeiro, A. J., Neufeld, R. Arnaud, P. Chaumeil, J. C. (1999). Microencapsulation of lipophilic drugs in chitosan-coated alginate microspheres. International Journal of Pharmaceutics, Vol. 187,1, (September 1999), pp. (115-123), ISSN 0378-5173 Rubinstein, A. (1995). Approaches and opportunities in colon-specific drug-delivery. Critical Reviews in Therapeutic Drug Carrier Systems, Vol 12, 2-3,1995), pp. (101-149), ISSN 0743-4863... 

The steroid microsphere systems are probably the most successful drug delivery formulations thus far ba.sed on lactide/glycolide polymers. Several of these products appear to be on track for human and animal applications in the 1990s. The success of these formulations is due to the known safety of the polymer, the reproducibility of the microencapsulation process, reliability in the treatment procedure, and in vivo drug release performance (80). 

The potential of liposomes in oral drug delivery has been largely disappointing. However, the use of polymer-coated, polymerized, and microencapsulated liposomes have all increased their potential for oral use [63], and it predicted that a greater understanding of their cellular processing will ultimately lead to effective therapies for oral liposomes. 

Wakerly, Z., Fell, J.T., Attwood, D., and Parkins, D., Peetin/ethyl eellulose film-eoating formulations for colonic drug delivery, Pharm. Res., 13 1210-1212 (1996). Lorenzo-Lamosa, M.L., Remunan-Lopez, C., Vila-Jato, J.L., and Alonso, M.J., Design of microencapsulated chitosan microspheres for colonic drug delivery, J. Contr. Rel, 52 109-118 (1998). 

Schwarz C. and Mehnert W., Solid lipid nanoparticles (SEN) for controlled drug delivery. 11. Drug incorporation and physicochemical characterization, J. Microencapsulation, 16, 205, 1999. 

A composition based on diketopiperazine derivatives (3,6-bis (N-fumaryl-N-(n-butyl) amino-2, 5-diketopiperazine) has been investigated as a pulmonary drug delivery system, termed Technospheres (Pharmaceutical Discovery Corp., Elmsford, NY) (Pohl et al. 2000 Steiner et al. 2002). The diketopiperazine derivatives self-assemble into microparticles at low pH with a mean diameter of approximately 2 pm. During self-assembly, diketopiperazine derivatives microencapsulate peptides present in the solution. Insulin incorporated in diketopiperazine derivatives (TI) was administered to five healthy humans by the use of a capsule-based inhaler with a passive powder deagglomeration mechanism. Relative and absolute bioavailability of TI in the first 3 hours (0-180 min) were 26 12% and 15 5%, and for 6 hours (0-360 min) 16 8% and 16 6%, respectively (Steiner et al. 2002). The time to peak action for glucose infusion rates was shorter with both IV (14 6 min) injection and inhalation (39 36 min), as compared to SC administration (163 25 min). This rapid absorption of insulin would be beneficial for diabetic patients who need to rapidly affect their glucose levels. 

Lee, J.H., T.G. Park, and H.K. Choi. 1999. Development of oral drug delivery system using floating microspheres. J Microencapsul 16 715. 

Singh, M., et al. 1993. Liposomal drug delivery to the eye and lungs A preliminary electron microscopy study. J Microencapsul 10 35. 

Foldvari, M., Effect of vehicle on topical liposomal drug delivery petrolatum bases, J. Microencapsul., 13, 589, 1996. 

Dhoot, N. O., and Wheatley, M. A. (2003), Microencapsulated liposomes in controlled drug delivery Strategies to modulate drug release and eliminate the burst effect, /. Pharm. Sci., 92(3), 679-689. 

Martinac, A., Filipovic-Grcic, J., Perissutti, B., Voinovich, D., and Pavelic, Z. (2005), Spray-dried chitosan/ethylcellulose microspheres for nasal drug delivery Swelling study and evaluation of in vitro drug release properties,/. Microencapsul., 22, 549-561. 

Microencapsulation Methods and Industrial Applications, edited by Simon Benita 74. Oral Mucosal Drug Delivery, edited by Michael J. Rathbone... 

Lorenzo-Lamosa ML, Remunan-Lopez C, Vila-Jato JL, and Alonso MJ. Design of microencapsulated chitosan microspheres for colonic drug delivery. J. Control. Rel. 1998 52 109-118. 

Formulation and/or development of advanced drug-delivery systems such as microencapsulated molecules, transdermal patches, or liposomes are frequently accomplished in the laboratory. However, large-scale production of these dosage forms may be problematic because the same conditions of manufacture may not be attainable or desirable in the plant setting. Consultation with process development personnel during the finalization of the prototype development phase is one way of minimizing scale-up difficulties. 

Meisner D, Pringle J, Mezei M. Liposomal pulmonary drug delivery. I. In vivo disposition of atropine base in solution and liposomal form following endotracheal instillation to the rabbit lung. J Microencapsul 6(3) 379-387, 1989. 

Haghpanah M, Marriott C, Martin GP. Potential use of microencapsulation for sustained drug delivery to the respiratory tract. J Aerosl Med 7(2) 185—188, 1994. 

De TK, Bergey EJ, Chung JS, et al. Polycarboxylic acid nanoparticles for ophthalmic drug delivery an ex vivo evaluation with human cornea. J Microencapsul 2004 21 841-855. 

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