Drug delivery nasal

Nasal administration of drugs is often difficult because of the poor membrane permea-bihty and less contact time due to the high turnover rate of secretion in the nasal passage, which ultimately reduces the nasal bioavailability of drugs. The exclusive properties of chitosan, i.e., bioadhesiveness and opening of tight intercellular jimctions, have made it 

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Wu J, Wei W, Wang LY, Su ZG, Ma GH (2007) A thermosensitive hydrogel based on quatemized chitosan and polyethylene glycol) for nasal drug delivery system. Biomaterials 28 2220-2232. 

Keywords Nasal drug delivery Preclinical drug development In situ Ex vivo, Drug metabolism Drug transport... 

Interest in nasal drug delivery has grown unabatedly the last 15 years. This is due to the several advantages the nose presents with respect to drug delivery, some of which include [1] the following ... 

Although this section deals mainly with the advantages of excised tissues with respect to nasal drug delivery studies, it is important to highlight some important attributes of nasal in situ perfusion model. Although this method does not provide data on systemic absorption, it enables study of the interactions of nasal mucosal enzymes, peptide substrates, and metabolic inhibitors and their implications for nasal drug absorption [13], It also enables the rate of nasal drug absorption to be determined. 

Specific Applications of in Situ Methods in Nasal Drug Delivery Studies... 

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Physiological Factors Affecting Nasal Drug Delivery... 

Administration of drug to the therapeutic target site or absorption site in the nasal cavity is the first step in nasal drug delivery. Uniform distribution over the affected area is desirable for the treatment of nasal symptoms, whereas targeting of the favorable absorption sites... 

The challenge for the future is not to let physiological barriers prevent the realization of the unique opportunities offered by nasal drug delivery for safe and effective drug therapy. 

Martin, E., et al. 1998. Nasal mucociliary clearance as a factor in nasal drug delivery. Adv Drug Deliv Rev 29 13. 

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