Drug delivery colon-specific

Guar gum could potentially be used as a biodegradable material for the preparation of colon specific delivery systems of drugs, by 

---

Ribeiro, A. J., Neufeld, R. Arnaud, P. Chaumeil, J. C. (1999). Microencapsulation of lipophilic drugs in chitosan-coated alginate microspheres. International Journal of Pharmaceutics, Vol. 187,1, (September 1999), pp. (115-123), ISSN 0378-5173 Rubinstein, A. (1995). Approaches and opportunities in colon-specific drug-delivery. Critical Reviews in Therapeutic Drug Carrier Systems, Vol 12, 2-3,1995), pp. (101-149), ISSN 0743-4863... 

DR Friend. Colon-specific drug delivery. Adv Drug Del Rev 7 149-199, 1991. 

Saffran, M., Oral Colon-Specific Drug Delivery With Emphasis on Insulin, in Oral Colon-Specific Drug Delivery (D. R. Friend Ed.), pp. 115-142. CRC Press, Boca Raton (1992). 

Gardner N, Haresign W, Spiller R, Farraj N, Wiseman J, Norbury H, Ilium L (1996) Development and validation of a pig model for colon-specific drug delivery. J. Pharm. Pharmacol 48 pp 689-693. 

Colon-specific drug delivery is primarily dependent on two physiological factors, the pH and the transit time. 

Haeberlin, B., and Friend, D.R., Anatomy and physiology of the gastrointestinal tract. In Oral Colon-specific Drug Delivery (D.R. Friend, ed.), CRC Press, Boca Baton, 1992, pp. 1-43. 

Friend, D.R., and Tozer, T.N., Drug glycosides in oral colon-specific drug delivery, J. Contr. Pel, 19 109-120 (1992). 

Minami, K., Hirayama, F., and Uekama, K., Colon-specific drug delivery based on a cyclodextrin prodrug release behavior of biphenylylacetic acid from its cyclodextrin conjugates in rat intestinal tracts after oral administration, J. Pharm. Sci., 87 715-720 (1998). 

Ishibashi, T., Pitcairn, G.R., Yoshino, Ft., Mizobe, M., and Wilding, I.R., Scintigraphic evaluation of a new capsule-type colon specific drug delivery system in healthy volunteers, J. Pharm. Sci., 87 531-535 (1988). 

Ueda, T., Yamaoki, T., Miyamoto, M., Kimura, Y., Sasatani, H., and Kim, S.I., Baeterial reduction of azo compounds as a model reaction for the degradation of azo-eontaining polyurethane by the action of intestinal flora. Bull Chem. Soc. Jpn., 69 1139-1142 (1996). Krishnaiah, Y.S., Satyanarayana, S., and Prasad, Y.V., Studies of guar gum eompression-coated 5-aminosalicylic acid tablets for colon-specific drug delivery. Drug-Dev. Ind. Pharm., 25 651-657 (1999). 

Prasad, Y.V., Krishnaiah, Y.S., and Satyanarayana, S., In vitro evaluation of guar gum as a carrier for colon-specific drug delivery, J. Contr. Rel, 51 281-287 (1998). 

Tozaki, H., Fujita, T., Odoriba, T., Terabe, A., Okabe, S., Muranishi, S., and Yamamoto, A., Validation of a pharmacokinetic model of colon-specific drug delivery and the therapeutic effects of chitosan capsules containing 5-aminosalicylic acid on 2,4,6-trinitrobenzenesul-phonic acid-induced colitis in rats, J. Pharm. Pharmacol, 51 1107-1112 (1999). 

Aiedeh, K., and Taha, M.O., Synthesis of chitosan succinate and chitosan phthalate and their evaluation as suggested matrices in orall administered, colon-specific drug delivery systems, Arch. Pharm (Weinheim), 332 103-107 (1999). 

Rubinstein, A., Nakar, D., and Sintov, A., Chondroitin sulfate a potential biodegradable carrier for colon-specific drug delivery, Int. J. Pharm., 84 141-150 (1992). 

Munjeri, O., Collet, J.H., and Fell, J.T., Hydrogel beads based on amidated pectins for colon-specific drug delivery Role of chitosan in modifying drug release, J. Contr. Rel., 46 273-278 (1997). 

Simonsen, L., Hovgaard, L., Mortensen, P.B., and Brondsted, H., Dextran hydrogels for colon-specific drug delivery. Degradation in human intestinal incubation models, Eur. J. Pharm. Sci., 3 329-337 (1995). 

Chiu, H.C., Hsiue, G.H., Lee, Y.P., and Huang, L.W., Synthesis and characterization of pH-sensitive dextran hydrogels as a potential colon-specific drug delivery system, J. Biomater. Sci. Polym. ed., 10 591-608 (1999). 

A Practical Approach in the Design of Colon-specific Drug Delivery Systems... 

---