Drugs advanced delivery systems

Davis, S. S. In Advanced Delivery Systems for Peptides and Proteins—Pharmaceutical Considerations Delivery Systems for Peptide Drugs Davis, S. S., Ilium, L., Tomlinson, E., Eds. Plenum Press New York, 1986, pp. 1-21. 

Edwards-Levy, F., Andry, M. C. Levy, M. C. (1994). Determination of free amino group content of serum-albumin microcapsules. II. Effect of variations in reaction-time and terephthaloyl chloride concentration. International Journal of Pharmaceutics, Vol. 103, 3, (March 1994), pp. (253-257), ISSN 0378-5173 Friend, D. R. (2005). New oral delivery systems for treatment of inflammatory bowel disease. Advanced Drug Delivery Reviews, Vol. 57, 2, (January 2005), pp. (247-265), ISSN 0169-409X... 

Liu, Z., Jiao, Y., Wang, Y., Zhou, C. Zhang, Z. (2008). Polysaccharides-based nanoparticles as drug delivery systems. Advanced Drug Deliver / Reviews, Vol. 60, 15, (December 2008), pp. (1650-1662), ISSN 0169-409X... 

T., Katutani, Y., and Kitsugi, T., Release of antibiotics from composites of hydroxyapatite and poly(lactic acid), in Advances in Drug Delivery Systems (J. M. Anderson and S. W. Kim, eds.), Elsevier, New York, 1986, pp. 179-186. 

As pharmaceutical scientists gain experience and tackle the primary challenges of developing stable parenteral formulations of proteins, the horizons continue to expand and novel delivery systems and alternative routes of administration are being sought. The interest in protein drug delivery is reflected by the wealth of literature that covers this topic [150-154]. Typically, protein therapeutics are prepared as sterile products for parenteral administration, but in the past several years, there has been increased interest in pulmonary, oral, transdermal, and controlled-release injectable formulations and many advances have been made. Some of the more promising recent developments are summarized in this section. 

GM Zentner, GS Rork, KJ Himmelstein. Osmotic flow through controlled porosity films An approach to the delivery of water soluble compounds. In JM Anderson, SW Kim, eds. Advances in Drug Delivery Systems. New York Elsevier, 1986, pp 217-230. 

Recent developments in polymer chemistry have allowed for the synthesis of a remarkable range of well-defined block copolymers with a high degree of molecular, compositional, and structural homogeneity. These developments are mainly due to the improvement of known polymerization techniques and their combination. Parallel advancements in characterization methods have been critical for the identification of optimum conditions for the synthesis of such materials. The availability of these well-defined block copolymers will facilitate studies in many fields of polymer physics and will provide the opportunity to better explore structure-property relationships which are of fundamental importance for hi-tech applications, such as high temperature separation membranes, drug delivery systems, photonics, multifunctional sensors, nanoreactors, nanopatterning, memory devices etc. 

Silica particles A novel drug-delivery system. Advanced Materials, 16, 1959-1966. 

O Hagan DT (1998) Recent advances in immunological adjuvants the development of particulate antigen delivery systems. Exp Opin Invest Drugs 7 349-359... 

Kim, S. W., Temperature Sensitive Polymers for Delivery of Macromolecular Drugs, in Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems (N. Ogata, et al., Eds.), pp. 125-133. Springer, Tokyo (1996). 

Kompella, U.B. and Lee, V.H.L. 2001. Delivery systems for penetration enhancement of peptide and protein drugs design considerations. Advanced Drug Delivery Reviews 46, 211-245. 

N. Bodor, Novel Approaches to the Design of Safer Drugs Soft Drugs and Site-Specific Chemical Delivery Systems , in Advances in Drug Research , Ed. B. Testa, Academic Press, London, Vol. 13, 1984, p. 255-331. 

An important application of polymers in medicine is in advanced drug-delivery systems. These materials control the drug concentration and delivery rate in the body. Hyperbranched polyesters have been suggested for such systems [111]. However, most applications within this field, described in the literature, deal with dendrimers and not with hyperbranched polymers. 

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