Glycolide-l-lactide

Suitable 2-hydroxy carboxylic acid derivatives are the cyclic dimers glycolide, L-lactide, D-lactide and meso-lactide, as well as lactic acid esters and lactic acid oligomers (37). 

Glycolide L-lactide copolymers Lactide trimethylene carbonate copolymers Lactide tetramethylglycolide copolymers Lactide a-valerolactone copolymers Methacrylate N-vinyl-pyrrolidone copolymers Lactic acid ethylene oxide copolymers... 

N., Karal-Yilmaz, O., Cvetkovska, M., Baysal, K., and Baysal, B.M. (2002) Synthesis and characterization of glycolide, L-lactide, and PDMS-based terpoly-mers as a support for cell cultures. 

Natural collagen-based absorbable sutures have largely been replaced by synthetic absorbable sutures. Synthetic absorbable sutures are made from aliphatic absorbable polyesters and contain one or more of the five basic building blocks glycolide,L-lactide,p-dioxanone, -caprolactone and trimethylene carbonate. With the exception of the trimethylene carbonate building block which results in amorphous polymers, the polymers from the other four blocks are semicrystaUine. 

Ethicon introduced a similar glycolide-L-lactide copolymer suture in the late 1990s Panacryl. They basically reversed the molar ratio of glycohde to L-lactide, 5/95 molar ratio of glycolide to L-lactide. As a result of the predominant L-lactide component in Panacryl suture, its absorption behaves... 

Poly(glycolide/L-lactide) copolymer at 90% glycolide and 10% L-lactide Polyglactin 910 Coated vicryl Braided or monofilament... 

Scanning electron images of some commercial absorbable sutures (a) Chromic catgut polyglycolic acid family (b) Dexon poly(glycolide/L-lactide) copolymer or polyglactin 910 family ... 

Monocryl Plus), and poly(gycolide/p-dioxanone/trimethylene carbonate) triblock copolymer (e.g., Biosyn ), poly(glycolide/ -caprolactone/trimeth-ylene carbonate) triblock copolymer (Monosyn ), poly(glycolide/L-lactide/ -caprolactone/trimethylene carbonate) teriblock copolymer (Caprosyn ), and 100% poly-L-lactide (Orthodek ) (Chu et al., 1997). 

Poly(glycolide/L-lactide) Coated Vicryl Braided or... 

Small-scale Polymerization of Glycolide, L-lactide, and DL-lactide... 

Bioresorbable linear aliphatic polyesters (e.g., polyglycolide, polylactide, polycaprolactone, polyhydroxybutyrate) and their copolymers within the aliphatic polyester family like poly(glycolide-L-lactide) copolymer and poly(glycolide-E-caprolactone) copolymer. 

Copolymers of glycolide L(-)lactide have been commercialized for biomedical applications and are high strength biodegradable thermoplastic materials. Poly(glycolic acid) and copolymers with D,L-lactides are presumed to be biodegradable, although the role of chemical hydrolysis vs. enzymatic depolymerization in this process remains open to debate. 

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