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Fatty acid membranes

The free fatty acid uptake by tissues is related directly to the plasma free fatty acid concentration, which in turn is determined by the rate of lipolysis in adipose tissue. After dissociation of the fatty acid-albumin complex at the plasma membrane, fatty acids bind to a membrane tty acid transport protein that acts as a transmembrane cotransporter with Na. On entering the cytosol, free fatty acids are bound by intracellular fatty acid-binding proteins. The role of these proteins in intracellular transport is thought to be similar to that of serum albumin in extracellular transport of long-chain fatty acids. [Pg.207]

Punnonen, K., Jansen, C.T., Puntala, A. and Ahotupa. M. (1991b). Effects of in vitro UVA irradiation and PUVA treatment on membrane fatty acids and activities of anti-oxidant enzymes in human keratinocytes. J. Invest. Dermatol. 96, 255-259. [Pg.124]

Campbell, F.M., Gordan, M.J., Taffasse, S. and Dutta-Roy, A.K. (1995) Plasma membrane fatty acid-binding protein from human placenta identification and characterization. Biochemical and Biophysical Research Communications 209, 1011-1017. [Pg.333]

Procedure Harvest the algal cells by centrifugation at 3000 rpm for 5 min at 4°C, then, wash the cells in distilled water thrice. Prepare three replicates for each treatment. Sonicate the algal cells under nitrogen condition at 14 MHz for 10 min to extract the membrane fatty acids. Add 2 ml of 2 M KOH in 95% (v/v) methanol and 2 ml of benzene to the sonicated cells. Fill the headspace with N2 gas and incubate the mixture at 80°C for 3 h. On cooling, add an equal volume of methanol and extract the non-saponified fraction by... [Pg.170]

Bums, C. P., and Spector, A. A, 1987, Membrane fatty acid modification in tumor cells a potential therapeutic adjunct, Lipids 22 178-184. [Pg.117]

Ramesh B, Viswanathan P, Pugalendi KV. (2007) Protective effect of Umbelliferone on membranous fatty acid composition in streptozotocin-induced diabetic rats. Eur J Pharmacol 566 231-239. [Pg.596]

Fate of fatty acids The free (unesterified) fatty acids move through the cell membrane of the adipocyte, and immediately bind to albumin in the plasma. They are transported to the tis sues, where the fatty acids enter cells, get activated to their CtA derivatives, and are oxidized for energy. [Note Active transport of fatty acids across membranes is mediated by a membrane fatty acid binding protein.] Regardless of their blood levels, plasma free fatty acids cannot be used for fuel by erythrocytes, which have no mitochondria, or by the brain because of the imperme able blood-brain barrier. rr f-... [Pg.188]

Likewise in the single study involving type 2 diabetes, Krachler et al. (2008) measured 15 0 and 17 0 in erythrocyte membrane fatty acids and investigated their relation to the development of type 2 diabetes mellitus. The study included 159 individuals with type 2 diabetes mellitus and 291 sex- and age-matched controls. Higher proportions of 15 0 and 17 0 were associated with a lower risk of diabetes. After adjustment for BMI, HbAlc, alcohol intake, smoking, and physical activity, the association between the milk fat biomarkers and diabetes remained (Krachler et al., 2008). [Pg.26]

AB Rifkind Cornell University Medical Center, Ithaca, NY Use a chick embryo model to investigate whether 2,3,7,8-TCDD-induced P-450 participates in 2,3,7,8-TCDD toxicity by metabolizing endogenous compounds, such as the membrane fatty acid, arachidonic acid (AA), to biologically active metabolites that can affect cell signals and thereby modulate toxicity ... [Pg.377]

FABPs have been implicated in transmembrane and intracellular transport of fatty acids (Veerkamp et al., 1991 Storch and Thumser, 2000). These are a group of tissue-specific proteins of about 14-15 kDa that bind long-chain fatty acids (C16-C20) with high affinity and a molar stoichiometry of 1 1. Most bind unsaturated fatty acids with higher affinity than saturated fatty acids. In addition to transport functions it has been proposed that they modulate specific enzymes of lipid metabolism, regulate expression of fatty acid-responsive genes, maintain cellular membrane fatty acid levels, and reduce the concentration of fatty acids in the cell, thereby removing their inhibitory effect on metabolic processes. [Pg.49]

Ctrl = 6M,5F Antipsychotic-naive MRSI blood cell membrane fatty acid content No correlations found in occipital, inferior parietal, superior temporal regions or BG... [Pg.429]

Howlett, N. G. Avery, S. V. (1997). Relationship between cadmium sensitivity and degree of plasma membrane fatty acid unsaturation in Saccharomyces cerevisiae. [Pg.262]

To determine the shape of the hydrophobic barrier of bilayer membranes, fatty acids and PC molecules spin labeled with nitroxides at various positions along the lipid chains were diffused into vesicles and their solvent-sensitive isotropic coupling constants were measured [54]. Results are plotted in Figure 5 in terms of distance of the probe from the bilayer center. Also shown is the profile of the dielectric constant along the membrane normal evaluated from the fluorescence lifetime distribution of fluorescence probes in PC liposomes [55]. These data correlate well with results from neutron diffraction studies that map the positional distribution of water and lipid moieties along the bilayer normal [56]. [Pg.2964]

Serum levels of phospholipids dfiiomo-gamma-linolenic acid were also found to be inversely associated with the risk of death caused by lung cancer (60). In diabetic rats, GLA was found to have beneficial, restorative effects on nerve conduction velocity, Na-f, K+ ATPase activity, and membrane fatty acid composition (61). Moreover, bleomycin-induced lung fibrosis in hamsters was altered as a result of elevations in tissue PGEl and 15-HETrE, both of which have anti-inflammatory properties (62). [Pg.558]

Seiss W, Scherer B, Bohlig B, Roth P, Kurzman L and Weber PC. (1980). Platelet-membrane fatty acids, platelet aggregation, and thromboxane formation during Mackrel diet Lancet 1,441-444. [Pg.289]

Ranganath LR, Christolides JA, Wright JW, and Marks V. (1996). Effects of hormone replacement therapy on platelet membrane fatty acid composition. J. Endocrinol. 148,207-212. [Pg.292]

The major function of vitamin E is to act as a natural cmtioxidant by scavenging free radicals and molecular oxygen. In particular vitamin E is important for preventing peroxidation of polyunsaturated membrane fatty acids. [Pg.240]

Several observations can be made- One of the major fatty acids of butler is 14 0. Obviously, this fatty add was not incorporated into the phospholipids of the membrane. Fatty acids with 14 carbons were essentially absent from the membranes, The food lipids did not contain Song-chain fatty acids of 20 or 22 carbons however, the membranes contained substantial amounts of these acids. For example, about 20% of ihe fatty add content of the membranes of the com oil-fed rat was 20 4,... [Pg.321]

Fukuwatari T, Kawada T, Tsuruta M, Hiraoka T, Iwanaga T, Sugimoto E, Fushiki T (1997) Expression of the putative membrane fatty acid transporter (FAT) in taste buds of the circum-vallate papillae in rats. FEBS Lett 414 461-464... [Pg.247]

A significant ATR has been found in S. typhimurium, following culture in acidic environments (pH 3.0). Modifications in the membrane fatty acid composition of S. typhimurium, however, have not been found dependent on the pH or the acid used for acidification (Alvarez-Ordonez et al., 2009). Shigella is another organism known to survive for extended periods in unfavorable conditions such as high acid or high temperature (Lin et al., 1995 Tetteh and Beuchat, 2003). [Pg.214]

S.L. Zhou, D. Stump, D. Sorrentino, B.J. Potter, and P.D. Berk, Adipocyte differentiation of 3T3-L1 cells involves augmented expression of a 43-kDa plasma membrane fatty acid-binding protein, J. Biol. Chem., 1992, 267, 14456-14461. [Pg.331]

Park CC, Ahmed Z. Alterations of plasma membrane fatty acid composition modify the kinetics of Na current in cultured rat diencephalic neurons. Brain Res 1992 570 75-84. [Pg.77]

Benolken RM, Anderson RE, Wheeler TG. Membrane fatty acids associated with the electrical response in visual excitation. Science 1973 182 1253-1254. [Pg.111]

Earlier studies examining the role of dietary fat on brain membrane composition have used rodents that were fed 18 2n-6-deficient diets for several weeks to a few generations. Results from these studies demonstrate qualitative changes in brain membrane fatty acid composition associated with essential fatty acid deficiency (i.e., increase in 20 3n-9 and decrease in 20 4n-6 Koblin et al., 1980 Paoletti Galli, 1972 Sun Sun, 1974). [Pg.164]


See other pages where Fatty acid membranes is mentioned: [Pg.536]    [Pg.321]    [Pg.131]    [Pg.82]    [Pg.16]    [Pg.171]    [Pg.174]    [Pg.353]    [Pg.137]    [Pg.179]    [Pg.213]    [Pg.397]    [Pg.152]    [Pg.218]    [Pg.472]    [Pg.284]    [Pg.320]    [Pg.483]    [Pg.250]    [Pg.128]    [Pg.275]    [Pg.90]    [Pg.165]   
See also in sourсe #XX -- [ Pg.343 , Pg.344 ]

See also in sourсe #XX -- [ Pg.93 , Pg.94 , Pg.95 , Pg.96 , Pg.97 , Pg.98 , Pg.99 , Pg.100 , Pg.101 , Pg.102 , Pg.103 ]




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Cell membranes fatty acids

Fatty acid in membrane phospholipids

Fatty acid-transport protein, membrane

Fatty acids adaptation membranes

Fatty acids in membranes

Fatty acids membrane composition

Fatty acids membrane phospholipid

Fatty acids membrane transport

Fatty acids membrane, hydrophobic

Free fatty acids membrane separation

Membrane essential fatty acids

Membrane lipids fatty acids

Membranes, Lipids, and Fatty Acids

Membranes, unsaturated fatty acids

Plant cell membranes, fatty acid

Polyunsaturated fatty acids adaptation, membranes

Schizophrenia membrane fatty acid levels

Transport of fatty acids across the membrane

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