Fatty acids cell membranes

Ctrl = 6M,5F Antipsychotic-naive MRSI blood cell membrane fatty acid content No correlations found in occipital, inferior parietal, superior temporal regions or BG... 

Doris AB, Wahle K, MacDonald A, Morris S, Coffey 1, Muir W, et al. Red cell membrane fatty acids cytosolic phospholipase A2 and schizophrenia. Schizophr Res 1998 31 185-196. 

Vicario, I. M., Maikova, D., Lund, E. K. Johnson, I. T. (1998). Olive oil supplementation in healthy adults effects in cell membrane fatty acid composition and platelet function. Annals of nutrition metabolism, 42(3), 160-9. 

Procedure Harvest the algal cells by centrifugation at 3000 rpm for 5 min at 4°C, then, wash the cells in distilled water thrice. Prepare three replicates for each treatment. Sonicate the algal cells under nitrogen condition at 14 MHz for 10 min to extract the membrane fatty acids. Add 2 ml of 2 M KOH in 95% (v/v) methanol and 2 ml of benzene to the sonicated cells. Fill the headspace with N2 gas and incubate the mixture at 80°C for 3 h. On cooling, add an equal volume of methanol and extract the non-saponified fraction by... 

Bums, C. P., and Spector, A. A, 1987, Membrane fatty acid modification in tumor cells a potential therapeutic adjunct, Lipids 22 178-184. 

There are three major fuels for cells glucose, fatty acids and glutamine (Chapter 9). Transporter molecules are present in the membrane for each of these fuels. 

Fate of fatty acids The free (unesterified) fatty acids move through the cell membrane of the adipocyte, and immediately bind to albumin in the plasma. They are transported to the tis sues, where the fatty acids enter cells, get activated to their CtA derivatives, and are oxidized for energy. [Note Active transport of fatty acids across membranes is mediated by a membrane fatty acid binding protein.] Regardless of their blood levels, plasma free fatty acids cannot be used for fuel by erythrocytes, which have no mitochondria, or by the brain because of the imperme able blood-brain barrier. rr f-... 

AB Rifkind Cornell University Medical Center, Ithaca, NY Use a chick embryo model to investigate whether 2,3,7,8-TCDD-induced P-450 participates in 2,3,7,8-TCDD toxicity by metabolizing endogenous compounds, such as the membrane fatty acid, arachidonic acid (AA), to biologically active metabolites that can affect cell signals and thereby modulate toxicity ... 

FABPs have been implicated in transmembrane and intracellular transport of fatty acids (Veerkamp et al., 1991 Storch and Thumser, 2000). These are a group of tissue-specific proteins of about 14-15 kDa that bind long-chain fatty acids (C16-C20) with high affinity and a molar stoichiometry of 1 1. Most bind unsaturated fatty acids with higher affinity than saturated fatty acids. In addition to transport functions it has been proposed that they modulate specific enzymes of lipid metabolism, regulate expression of fatty acid-responsive genes, maintain cellular membrane fatty acid levels, and reduce the concentration of fatty acids in the cell, thereby removing their inhibitory effect on metabolic processes. 

In aerobic cells, polyunsaturated fatty acids of membrane phospholipids easily undergo such oxidative chain reactions [111,112]. This is because the double bonds of the polyunsaturated structure are repeatedly connected to each other by c/s-methylene units. Such bis-allylic structures enable electron delocalization on five carbon atoms, making the initial hydrogen abstraction on... 

S.L. Zhou, D. Stump, D. Sorrentino, B.J. Potter, and P.D. Berk, Adipocyte differentiation of 3T3-L1 cells involves augmented expression of a 43-kDa plasma membrane fatty acid-binding protein, J. Biol. Chem., 1992, 267, 14456-14461. 

Ikemoto A, Kobayashi T, Watanabe S, Okuyama H. Membrane fatty acid modifications of PC12 cells by arachidonate or docosahexaenoate affect neurite outgrowth but not norepinephrine release. Neurochem Res 1997 22(6) 671-678. 

A complex interplay of host and pathogen factors influences the acquisition and development of fungal infections. Intact skin or mucosal surfaces serve as primary barriers to infection. Desiccation, epithelial cell turnover, fatty acid content, and low pH of the skin are believed to be important factors in host resistance. Bacterial flora of the skin and mucous membranes compete with fungi for growth. Alterations in the balance of normal flora caused by the use of antibiotics or alterations in nutritional status can allow the proliferation of fungi such as Candida, increasing the likelihood of systemic invasion and infection. ... 

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