T cell signaling

Protein kinase C theta plays a critical role in T cell signaling and thus the inhibition of this enzyme has the potential to be useful for treating inflammatory diseases. Cywin et al. [55] describe the parallel optimization of potency against the enzyme,... 

Resta, R. and Thompson, L. F. T cell signalling through cd73. Cell Signal. 9 131-139,1997. 

Zeyda, M. et al., Suppression of T cell signaling by polyunsaturated fatty acids Selectivity in inhibition of mitogen-activated protein kinase and nuclear factor activation, J Immunol, 170, 6033, 2003. 

Mandel S, Weinreb O, Amit T, Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (—)-epigallocatechin-3-gallate, implications for neurodegenerative diseases, JNeurochem 88 1555—1569, 2004. 

Murphy, M. A., R. G. Schnall, D. J. Venter, L. Barnett, I. Bertoncello, C. B. Thien, W. Y. Langdon, and D. D. Bowtell. Tissue hyperplasia arul enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice. Mol Cell Biol. 18 4872-4882.1998. 

F.A. Etzkorn, L.A. Stolz, Z.Y. Chang, C.T. Walsh, Role of the cyclosporin-A-cyclophilin complex, FK506-FK506-binding protein complex and calcineurin in the inhibition of T-cell signal transduction, Curr. Opin. Struct. Biol. 3 (1993) 929-933. 

Normally, a small population of long-lived plasma cells in the bone marrow is the source of circulating IgG and IgA. The precursors of these cells are slowly proliferating plasmablasts. After stimulation by antigens and T cell signaling the plasmablasts migrate to the bone marrow from lymph nodes. A switch from IgM to... 

Taylor, D.D. and Gercel-Taylor, C. (2005) Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects. Br. J. Cancer 92, 305-311. 

Structurally diverse compounds like the undecapeptide cyclosporin A and the complex polyketide FK506 bind similar biological target molecules, the immuno-philins, and interfere with identical T cell signaling pathways. 

Webb Y, Hermida-Matsumoto L, Resh MD. Inhibition of protein palmitoylation, raft localization, and t cell signaling by 2-bromopalmitate and polyunsaturated fatty acids. J. Biol. Chem. 2000 275 261-270. 

In experimental models, the immunosuppressant cyclosporine A blocks T-cell signalling pathways by inhibiting the phosphatase calcineurin and may induce autoimmunity by impairing central tolerance... 

Saxena M, Williams S, Brockdorff J et al (1999) Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP). J Biol Chem 274 11693-11700... 

Liu, J., Albers, M. W., Wandless, T. J., et al. (1992). Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity. Biochemistry, 31, 3896-3901. 

Sundberg EJ, Li H, Llera AS, McCormick IK, Tormo J, Schlievert PM, Karjalainen K, Mariuzza RA Structures of two streptococcal superantigens bound to TCR (3 chains reveal diversity in the architecture of T cell signaling complexes. Structure 2002 10 687-699. 

Sundberg EJ, Li Y, Mariuzza RA So many ways of getting in the way diversity in the molecular architecture of superantigen-dependent T cell signaling complexes. Curr Opin Immunol 2002 14 36M4. 

Bueno C, Criado G, McCormick JK, Madrenas J T cell signaling induced by bacterial superantigens in Marone G (ed) Superantigens and Superallergens. Chem Immunol Allergy. Basel, Karger, 2007, vol 73, pp 161-180. 

Activation of T cell signaling pathways Increase in the expression of LFA-1 and cytokines... 

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