Bleomycin-induced lung fibrosis

Izbicki G, Or R, Christensen TG, et al. Bleomycin-induced lung fibrosis in IL-4-overexpressing and knockout mice. Am J Physiol Lung Cell Mol Physiol 2002 283(5) L1110-L1116. [Pg.317]

Nakao, A., Fujii, M., Matsumura, R., Kumano, K., Saito, Y., Miyazono, K. and Iwamoto, I. (1999). Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. J. Clin. Invest. 104, 5-11. [Pg.188]

Serum levels of phospholipids dfiiomo-gamma-linolenic acid were also found to be inversely associated with the risk of death caused by lung cancer (60). In diabetic rats, GLA was found to have beneficial, restorative effects on nerve conduction velocity, Na-f, K+ ATPase activity, and membrane fatty acid composition (61). Moreover, bleomycin-induced lung fibrosis in hamsters was altered as a result of elevations in tissue PGEl and 15-HETrE, both of which have anti-inflammatory properties (62). [Pg.558]

Shahzeidi, S., Mulier, B., de Crombru he, B., Jeffery, P.K., McAnulty, R.J. and Laurent, G.J. (1993). Enhanced type III collagen gene expression during bleomycin induced lung fibrosis. Thorax 48, 622-628. [Pg.225]

Zia, S., Hyde, D.M. and Giri, S.N. (1992). Effect of an interferon inducer bropirimine on bleomycin induced lung fibrosis in hamsters. Pharmacol. Toxicol. 71, 11-18. [Pg.226]

Poly (ADP-ribose) synthetase activity during bleomycin-induced lung fibrosis in hamsters. Exp. Mol. Pathol. 43 162-76... [Pg.88]

Wang Q, Giri, SN, Hyde DM, Nakashima JM, Javadi I. 1990. Niacin attenuates bleomycin-induced lung fibrosis in the hamster. J. Biochem. Toxicol. 5 13-22... [Pg.89]

O Neill CA, Giri SN. 1994. Biochemical mechanisms for the attenuation of bleomycin-induced lung fibrosis by treatment with niacin in hamsters the role of NAD and ATP. Exp. Lung Res. 20 41-56... [Pg.89]

Lasky JA, Ortiz LA, Tonthat B, Hoyle GW, Corti M, et al. 1998. Connective tissue growth factor mRNA expression is up-regulated in bleomycin-induced lung fibrosis. Am. Physiol. Soc. 275 L365-71... [Pg.90]

Iyer SN, Wild JS, Schiedt MJ, Hyde DM, Margolin SB, Giri SN. 1995. Dietary intake of pirfenidone ameliorates bleomycin-induced lung fibrosis in hamsters. J. Lab. Clin. Med. 125 779-84... [Pg.91]

Giri SN, Hyde DM. 1988. Ameliorating effect of an interferon inducer poly-inosinic-polycytidylic acid on bleomycin-induced lung fibrosis in hamsters morphologic and biochemical evidence. Am. J. Pathol. 133 525-36... [Pg.92]

Wang Q, Wang Y, Hyde DM, Gotwals PJ, Koteliansky VE, et al. 1999. Reduction of bleomycin induced lung fibrosis by transforming factor p soluble receptor in hamsters. Thorax 54 805-12... [Pg.92]

Giri SN, Sharma AK, Hyde DM, Wild JS. 1995. Amelioration of bleomycin-induced lung fibrosis by treatment with the platelet activating factor receptor antagonist WEB 2086 in hamsters. Exp. Lung Res. 21 287-307... [Pg.93]

Ziboh VA, Yun M, Hyde DM, Giri SN. 1997. y-linolenic acid-containing diet attenuates bleomycin-induced lung fibrosis in hamsters. Lipids 32 759-67... [Pg.96]

Azuma, A., Takahashi, S., Nose, M., Araki, K., Araki, M., Takahashi, T., Hirose, M., Kawashima, H., Miyasaka, M., and Kudoh, S. (2000). Role of E-selectin in bleomycin induced lung fibrosis in mice. Thorax 55, 147-152. [Pg.570]

PG (58). In subsequent studies (59), we isolated lung myofibroblasts from bleomycin-exposed rats and determined that these cells secreted increased amounts of TGF-pi and PG, as compared to fibroblasts from control animals. PG secretion was further enhanced by exogenous TGF-p and inhibited by anti-TGF-p antibodies and IFN-y. The role of PG is compounded by the ability of decorin to bind TGF-p, reducing its bioavailability (60). A number of studies conducted in transgenic mice have now shown that gene transfer, or transgene overexpression of decorin, can modulate bleomycin-induced lung fibrosis (61-63). [Pg.120]

Ebihara T, Venkatesan N, Tanaka R, Ludwig MS. Changes in extracellular matrix and tissue viscoelasticity in bleomycin-induced lung fibrosis. Temporal aspects. Am J Respir Crit Care Med 2000 162 1569-1576. [Pg.129]

Tokuda A, Itakura M, Onai N, Kimiira H, Kuriyama T, Matsushima K. Pivotal role of CCRl-positive leukocytes in bleomycin-induced lung fibrosis in mice. J Immunol 2000 164 2745-2751. [Pg.258]

Cabrera S., Sehnan M., Lonzano-Bolanos A., et al. 2013. Gene expression profiles reveal molecular mechanisms involved in the progression and resolution of bleomycin-induced lung fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 304(9) L593-L601. [Pg.525]

Coker RK, Laurent GJ, Shahzeidi S, Lympany PA, duBoisRM, Jeffery PK, McAnulty RJ. TGFpl, p2, p3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis. Am J Pathol 1997 150 981-991. [Pg.189]

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