Medicinal applications

In connection with their medicinal applications and activities to the respiratory system they showed antiallergic (83EUP80176 85USP4528288), antihistaminic [73BBA(304)693 85GEP(0)3427823 86EUP181282 ... 

Fig. 1 Heterocycles bearing a 2-pyridone moiety with wide range of medicinal applications. Amrinone WIN 40680 1 is a cardiotonic agent for the treatment of heart failure. ZAR-NESTRA 2 is a selective farnesyl protein inhibitor and NP048 3 is a pilicide with novel antibacterial properties. The 2-pyridones 4, 5 and 6 are schematic representations of the three categories of 2-pyridones that wiU be covered in this chapter i.e., substituted 2-pyridones 4, 2-quinolones 5 and other ring-fused 2-pyridones 6...

Seventy cannabinoids from C. sativa have been described up to 2005 [2j. Mostly they appear in low quantities, but some of them shall be mentioned in the following overview - especially because of their fimctions in the biosynthesis of A9-THC and their use in medicinal applications. 

Fig. 5) with olivetol (5.2) in the presence of boron trifluoride etherate, BF3 0C(C2H5)2 with CBD as a key intermediate. This one-step synthesis of A9-THC is also used for the production of synthetic dronabinol, which is used in the medicinal application named Marinol. The mechanism of this synthesis is particular described by Razdan et al. [71] and is shown in Fig. 5... 

The inhibition of the phosphorylation of IkBoc by celastrol in the NF-kB signaling pathway is not cell specific72-75 and thus significantly broadened the potential medicinal applications of natural triterpene QMs. Celastrol 76 has been evaluated in the treatment of Crohn s disease,76 which is a chronic relapsing inflammatory bowel disease. In the peripheral blood mononuclear cells, celastrol 76 reduced the levels of... 

Roberts M F and Wink M (1998), Alkaloids Biochemistry, Ecology, and Medicinal Applications, in Roberts M F and Wink M, Kluwer Academic Publishers, UK. 

J. Thuery in Microwaves Industrial, Scientific and Medicinal Applications, Ar-tech House, 1992. 

A number of different adjuvant preparations have been developed (Table 13.13). Most preparations also display some associated toxicity and, as a general rule, the greater the product s adjuvanticity, the more toxic it is likely to be. A few different adjuvants may be used in veterinary medicine however (for safety reasons), aluminium-based products are the only adjuvants routinely used in human medicine. Application of many of the aggressive adjuvant materials is reserved for selected experimentation purposes in animals. 

The tetrakis(thioglycosyl) 128a and 129a derivatives can act as potent photosensitisers in their potential medicinal applications, this being due to their important photophysical properties.80... 

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