Quinoxaline medicinal applications

Scarcely a single issue of Chemical Abstracts is published without reference to medicinal compounds containing the pyrazine or quinoxaline ring in some form, and hence it is impractical to list all applications of pyrazines, quinoxalines and phenazines. Some of the more important applications and natural products, particularly the more recent developments, are mentioned in this Section. 

Until now, several types of polycyclic aromatic nitrogen heterocycles have been known. In fact, heterocyclic synthesis plays an important role in modern life. Among the nitrogen heterocycles, quinoxaline and phenazine derivatives have attracted great interest because of their wide application in organic and medicinal chemistry. Many phenazine compounds are found in nature and are produced by bacteria. Quinoxalines are the fundamental components of several pharmacological active compounds and some antibiotics such as levomycin, echinomycin, and actinomycin (Bailly et al, 1999 Dell et al, 1975). 

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