Lotions, medicinal, applications

The first plant product commercially produced by plant cell culture was the prenylated anthraquinone shikonin 16, from the boraginaceous plant Lithospermum erythrorhizon Sieb. et Zucc. (Mitsui Petrochemical Industry Company) in 1983.25 Shikonin is used as a dye in cosmetics (lipsticks, soaps and lotions) and its production yield from cell cultures was over ten-fold its isolation yield from the intact plant.25 In practice, eight runs of two weeks each in a 200 L bioreactor could afford the amount of shikonin produced in four years by a 1 ha field of L. erythrorhizon 25 Shikonin has an interesting and pleiotropic biological profile, which includes insulin mimicry and interference with protein-protein interactions, but it has not yet found medicinal application.26... 

Dermatologic self-care products fcill under the law for cosmetics. The substances allowed for use in dermatological products are included in lists that come out of the EC Directives, (e.g., UV-filters in creams and lotions). The applicant has to notify these products to the Ministry of Public Health. He has to prepare a technical file that can be described as a simplified pharmaco-clinical file for medicines. This file has to be available upon request to the authorities. The applicant also hcis to appoint a responsible person (pharmacist, biologist, chemist) who declares that the contents of the file are compliant with legislation cuid that the product is safe for use. The formulation of the product has to be communicated (under secrecy agreement) to the National Antipoison Centre. This procedure became fully operative on July 1, 1999. 

The family Hamamelidaceae consists of 26 genera and about 100 species of shrubs or tress known to contain tannins and iridoids. The leaves are alternate, simple, and often palmately lobed. The flowers are small and appear in spikes. The fruits are woody, capsular, and scepticidal. In Western medicine, the dried leaves of Hamamelis virginiana (hamamelis, British Pharmaceutical Codex, 1963), yielding not less that 20% of alcohol (45%)-soluble extractive, have been used as astringents for the treatment of hemorrhoids. Hamamelis water (British Pharmaceutical Codex, 1969) made from the stems has been used as a cooling application to sprains and bruises and as a styptic remedy. It is also used in cosmetics and as active ingredient of eye lotions. 

As is known, diverse TAS, including proteolytic enzymes, are widely used in medicine for the treatment of wounds and burns (Belov et al., 1992 Filatov et al., 2002, 2013). However, there are some problems that hinder the application of enzymes and some other TAS. The first problem is caused by autolysis, that is, self-denaturation, of proteolytic enzymes in the liquid remedies. Numerous inhibiting ingredients, unfavorable pH, and increased temperatures cause acceleration of the denaturation process. Due to low stability, the proteolytic enzymes cannot be directly used in liquid remedies, such as creams, lotions, and other remedies, which limit their applications. 

Surfactants are organic compounds that possess surface-active properties. This unique property of the surfactant is due to the presence of hydrophilic and hydrophobic qualities in the same molecule. The hydrophilic part of the molecule has affinity toward the aqueous phase and the hydrophobic part of the molecule interacts with the oil phase. This unique property of the surfactant molecules helps in its movement toward the interface and reduces the surface tension between the two immiscible phases. This dual behavior of surfactant molecules is responsible for their wide range of application in products such as cleansers, creams, lotions, shampoos, agricultural products, and medicines. 

The NEOBEE oils are a series of high quality vegetable derived emollient oils. Their safety, excellent stability, and controlled range of lubricities have made them widely used in the cosmetic and pharmaceutical fields in applications such as bath oils, creams, lotions, lipsticks and glosses, make-up bases, pre- and after-shave lotions, flavor and fragrance carriers and extenders, and vehicles for vitamins, antibiotics and medicinals. 

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