Regenerative medicine applications

Matrix-based delivery has been investigated mostly for regenerative medicine applications. Regenerative medicine aims to regenerate tissue by implanting biocompatible and biodegradable scaffolds at sites of injury or disease. The implanted scaffold must provide the mechanical support for the growing tissue and the bio-... 

The major natural polymers currently in use are proteins and polysaccharides. Due to diverse physical and chemical properties, natural polymers play a key role in tissue engineering and regenerative medicine. In the following section, we describe some frequently used protein polymers for tissue engineering and regenerative medicine applications. 

Chitosan is one of the widely used biomaterials and has gained considerable attention in tissue engineering and regenerative medicine applications in recent decades. The importance comes from its biocompatibility, biodegradability and easy availability, as well as the possibility to be prepared in various forms such as films, membranes, nanoparticles, fibers, hydrogels and scaffolds. Chitosan is a linear polysaccharide and is obtained... 

In this chapter, the chemistry of PURs will be described, with particular reference to the synthesis of biodegradable PURs with tuneable properties with respect to specific regenerative medicine applications. 

Chiono, V., Nardo, T., CiardeUi, G., 2013h. Bioartificial biomaterials for regenerative medicine appUcations. In Regenerative Medicine Applications in Organ Transplantation. Academic Press. 

Sun, ., Tan, H., 2013. Alginate-based biomaterials for regenerative medicine applications. Materials 6, 1285-1309. 

Natural polymers have been extensively used for various TE applications (mainly bone, skin, and cartilage blood vessels hgaments) (Malafaya et al., 2007). The main advantages of this class of materials are their excellent biocompatibility and that some of them are major components of the ECM in natural tissues. Hence, being the natural substrate for cell adhesion, proliferation, and differentiation, they represent the ideal cell delivery vehicle for regenerative medicine applications. However, being... 

One of the major classes of synthetic bioresorbable polymers is that of aliphatic polyesters or poly(a-hydroxy acids). Poly(a-hydroxy acids) such as PGA, poly(lactic acid) (PLA) stereoisomers poly(L-lactic acid) (PLLA) and poly(D-lactic acid), and pol-y(lactic-co-glycolic acid) (PLGA) copolymers are the most widely used and most popular bioresorbable polymers since they received Food and Drug Administration (FDA) approval for clinical use in humans in different forms (eg, fibers for sutures, injectable forms) (Nair and Laurencin, 2007). These polymers are commonly used in regenerative medicine applications. An example is the InQu Bone Graft Extender Substitute (ISTO Technologies), an osteoconductive biosynthetic product used as bone graft substitute in the skeletal system to support new bone formation. The resorption rate of... 

Nanotechnology-Based Cell Engineering Strategies for Tissue Engineering and Regenerative Medicine Applications Joaquim Miguel Oliveira, Jodo Filipe Mano,... 

Presents synthetic tissues and organs that are currently under development for regenerative medicine applications... 

Our understanding of host-material interactions is improving over time. The often recited foreign-body response associated with the use of biomaterials is slowly transforming into a tissue healing response that can be beneficial towards tissue engineering and regenerative medicine applications. 

Rashidi, H., Yang, J., Shakesheff, K.M., 2014. Surface engineering of synthetic polymer materials for tissue engineering and regenerative medicine applications. Biomater. Sci. 2,1318-1331. 

Mitchell, A.C., Briquez, P.S., Hubbell, J.A., Cochran, J.R., 2016. Engineering growth factors for regenerative medicine applications. Acta Biomater. 30, 1-12. 

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