Medical applications transdermal drug delivery

Silicone functionalized PIB is particularly suitable as a pressure sensitive adhesive composition in medical applications including transdermal drug delivery applications (83). 

Medical. Medical tapes often have cloth or cloth-like backings for comfort and breathability. Numerous synthetic breathable, conformable nonwovens (eg, spunlaced polyester such as Sontara, a trademark of DuPont creped polypropylene) have been developed for such purposes. In some instances, film tapes are preferred to provide a barrier for wound coverage or to increase hydration to speed transdermal drug delivery. Electrically conductive adhesives are used for electrode applications. 

In the late 1950s, polyacrylate-based PSAs were developed [283] and gained a dominant market share in the following decades. To a smaller extent polyfvinyi ethers) are used in medical devices. For specific applications like transdermal drug delivery systems, ostomy mounts, and electrically conductive adhesives a variety of specialty polymers such as silicones, polyurethanes, and various hydrogels are applied. 

Due to the high surface area and relatively simple incorporation processes, textile materials have been widely used for controlled drug delivery in many diverse applications, where medicated prodncts are designed for wound care, transdermal drug delivery, antifungal and antimicrobial barriers, ophthalmic drug carriers, etc. Some of these applications are described below. 

Pressure-sensitive adhesives (PSAs) are materials used to bond other materials on their surfaces by the bonding processes of adhesion and cohesion. They have the abihty to adhere instantaneously (also known as tack), resist removal by peel, and hold their position when shear forces are applied. Pressure-sensitive adhesives have been utilized in a range of medical applications from simple pressure-sensitive tapes to implant adhesives. Silicone PSAs are commonly used in transdermal drug delivery systems drug-loaded adhesive... 

Applications Automotive - fascia bellows, brake cable jackets, CV joint boots, filler panels, side-body trim, tubing grommets, fabric laminates. Medical - catherter tubing, connectors, tubing, transdermal drug delivery patches. Films -... 

An approach published in 2001 based on research out of the Klibanov laboratory at MIT is to use ethanol [5]. Ethanol, isopropanol, and other alcohols have long been used successfully as penetration enhancers for medical applications. Ethanol is one of the first molecules to have been used as a transdermal enhancer, because its effects are so easily and well characterized and its systemic and local toxicities are understood. It is currently contained in commercial delivery systems for estradiol [17] and other bioactive molecules. Ethanol and isopropanol have been used in a variety of studies based on their effects on drug transport. More applications can be found in the patent literature [18]. 

Transdermal Controlled Systemic Medications, edited by Yie W. Chien Drug Delivery Devices Fundamentals and Applications, edited by Praveen Tyle... 

Although encapsulation using the emulsion solvent removal methods has been investigated for applications in transdermal. - nasal,pulmonary,and ophthalmic drug delivery, - the vast majority of papers addressed the most common routes the oral and the parenteral, for the delivery of medications. 

The applications of hydrogels in the production of medical items, resulting materials must have several features, which recommends them non-toxicity, functionability, sterilizability, biocompatibUity [115]. These characteristics are requires for wound dressings, drug delivery systems, transdermal systems, injectable polymers, implants, dental and ophthalmic applications, stimuli-responsive systems, hydrogel hybrid-type organs. 

Excipients can influence delivery from topical and transdermal medications. The propensity of the drug to migrate from the formulation to the application surface is affected by factors such as lipophilicity of the vehicle, drug solubility in the formulation, and effects of additives on the barrier properties of the skin or mucosal surface. 

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