Experimental systems transdermal drug delivery

A new generation of transdermal drug delivery (TDD) system was developed to contain one or more skin permeation enhancers in the surface adhesive coating layers. This TDD system has been found, experimentally, to release the enhancers to the surface of stratum corneum to modify the skin s barrier properties, prior to the controlled delivery of the active drug. The extent of enhancement in skin permeability appears to be dependent upon the chemical structure of drug to be delivered transdermally as well as the type and the concentration of enhancer used. The mechanism of skin permeation enhancement have been explored and are analyzed in this report. 

Disodium edetate has been used experimentally to investigate the stability and skin penetration capacity of captopril gel, in which disodium edetate was shown to exert a potent stabilizing effect, and may be used in the development of a transdermal drug delivery system. ... 

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