Transdermal-drug delivery

Transdermal delivery systems are used to deliver the drug across the skin, into the systemic circulation, to avoid its first pass metabolism and reduce gastrointestinal adverse events. The bioadhesive property and paracellular transport of chitosan has also been 

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R. R. Burnette, Transdermal Drug Delivery Developmental Issues and Research Initiatives., Marcel Dekker, Inc., New York, 1989, pp. 247—291. 

Takayama K, Takahara J, Fujikawa M, Ichikawa H, Nagai T. Formula optimization based on artificial neural networks in transdermal drug delivery. J Controlled Release 1999 62 161-70. 

Transferosomes represent another system of encapsulation using ultradeformable vesicle carriers for bioactive molecules, applied until now for direct transdermal drug delivery. They are built from polar lipids and have high flexibility, and are rich in unsaturated fatty acids and carotenoid pigments." ... 

Solution SHS-GC-FID was used for the determination of dichloromethane (DCM) in PC [222] and solid SHS-GD for the analysis of residual solvents in transdermal drug-delivery systems [223] and rest... 

Mechanisms of Transdermal Drug Delivery, edited by Russell O. Potts and Richard H. Guy... 

Transdermal Drug Delivery Second Edition, Revised and Expanded, edited by Richard H. Guy and Jonathan Hadgraft... 

Nevertheless, there are reports on enhancement of ocular drug absorption by bile salts [33], surfactants [200], and chelators [149], Newton et al. [35] demonstrated that Azone, an enhancer widely tested in transdermal drug delivery [201], increased the ocular absorption of cyclosporine, an immunosuppressant, by a factor of 3, thereby prolonging the survival of a corneal allograft. In 1986, Lee et al. [34] reported that 10 pg/mL cytochalasin B, an agent capable of condensing the actin microfilaments, increased the aqueous humor and iris-ciliary body concentrations of topically applied inulin (5 kDa) by about 70% and 700%, respectively, in the albino rabbit. 

Finally, in transdermal drug delivery, the hydration status of the skin can play an important role. The permeability of skin to various drug entities can be... 

Transdermal Drug Delivery Systems. PHA 5110 Pharmaceutics II, University of Florida, College of Pharmacy, Department of Pharmaceutics, http //www.cop.ufl.edu/safezone/prokai/pha5110/tdds.htm... 

Park, J.-H., Allen, M.G. and Prausnitz, M.R. (2005) Biodegradable polymer microneedles fabrication, mechanics and transdermal drug delivery. Journal of Controlled Release, 104, 51-66. 

Trans, commercial defoamer, 5 24 It Trans-cleaving ribozymes, 17 627 Transcription, 12 449 Transdermal drug delivery, 9 46-48 efficacy, 9 47 systems, 15 711... 

Silicones are frequently used in transdermal drug delivery. Recently, the use of loosely cross-linked silicone elastomer blends for this application was surveyed.537 The mechanisms of controlled drug release in the silicone-based systems have been studied,538 as silicones are evaluated for relatively new protein drug-delivery systems.5... 

Keywords Transdermal drug delivery Skin toxicity Microdialysis In vitro permeation In vitro penetration... 

P. W. Wertz and D. T. Downing. Stratum comeum Biological and biochemical considerations. In J. Hadgraft and R. Guy (eds.), Transdermal Drug Delivery, Marcel Dekker, New York, Basel, 1989, pp. 1-22. 

Manitz R, Lucht W, Strehmel K, Weiner R, Neubert R (1998) On mathematical modeling of dermal and transdermal drug delivery. J Pharm Sci 97 873-879. 

Ho CK (2004) Probabilistic modeling of peracutaneous absorption for risk-based exposure assessments and transdermal drug delivery. Statistical Methodology 1 47-69... 

R. Lipp, H. Laurent, C. Gunther, J. Riedl, P. Esperling, U. Tauber, Prodrugs of Gesto-dene for Matrix-Type Transdermal Drug Delivery Systems , Pharm. Res. 1998,15, 1419 -1424. 

Tiemessen, H.L.G.M., Nonionie Surfactant Systems for Transdermal Drug Delivery, Ph.D. Thesis Leiden University, The Netherlands, 1989. 

Henry White was born in Chapel Hill. North Carolina in 1956. He received a B.S. in Chemistry from the University of North Carolina in 1978 and a Ph.D. in Chemistry from the University of Texas at Austin in 1982. He held a postdoctoral appointment at the Massachusetts Institute of Technology from 1983 to 1984 and was on the faculty of the Department of Chemical Engineering and Materials Science at the University of Minnesota from 1984 to 1993. He is currently a Professor of Chemistry at the University of Utah. His research interests include magnetic-field-induced transport, oxide films and corrosion, iontophoretic transdermal drug delivery, and electrochemical phenomena at electrodes of nanometer dimensions. 

A is used in hormone replacement therapy B is available for transdermal drug delivery C has to be taken tv/ice daily D contains norgestimate... 

Govil SK. Transdermal drug delivery devices. In Tyle P, ed. Drug Delivery Devices. Fundamentals and Applications. New York Marcel Dekker, 1988 386 19. 

Walters KA. Transdermal drug delivery. In Florence AT, Salole EG, eds. Routes of Drug Administration. London Wright, 1990 78-136. 

Oie S. Drug distribution and binding. J CUn Pharmacol 1986 26 583-586. Potts RO and Guy RH (eds.). Mechanisms of Transdermal Drug Delivery. New York Decker, 1997. 

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