Hybrid hydrogels

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Yang JY, Xu CY, Kopeckova P et al (2006) Hybrid hydrogels self-assembled from hpma copolymers containing peptide grafts. Macromol Biosci 6 201-209... 

Li H, Wang DQ, Liu BL, Gao LZ (2004) Synthesis of a novel gelatin-carbon nanotubes hybrid hydrogel. Colloids and Surfaces B-Biointerfaces 33 85-88. 

Designs of Hybrid Hydrogels Conclusions and Future Perspectives References... 

Hybrid hydrogels are usually referred to as hydrogel systems whose components are at least two distinct classes of molecules, for example, synthetic polymers and biological macromolecules, interconnected either covalently or noncovalently. They have been of particular interest because... 

Figure 3 Schematic illustration of a hybrid hydrogel system—genetically engineered coiled-coil protein domains used to crosslink synthetic water-soluble polymers. Divalent transition metal ions are shown to form complexes with nitrogen-oxygen-donor ligands on the synthetic polymer side chains and the terminal histidine residues in the coiled coils.

Figure 6 Swelling of hybrid hydrogels in response to temperature. The hydrogels were prepared from HPMA-DAMA copolymers, Ni(II), and KS590 coiled coil. The gels were equilibrated in PBS (pH 7.4) at 25°C prior to an increase in temperature. Rate of heating l°C/min plus 2 min equilibration time. Arrows indicate elevated temperatures of 25°C, 35°C, and 45°C, respectively. Modihed from Reference [35].

Figure 7 Schematic diagram of the mechanism of temperature sensitivity of hybrid hydrogels.

Three-dimensional hybrid hydrogel networks were also prepared by the authors in the current application by functionalizing the step 5 derivatives with metha-cryloyl dextran. 

Fig. 20 Structural representation of the hybrid hydrogel of poly(HMPA-co-DAMA) connected to a His-tagged coiled coil via a Np complex. Reprinted with permission from [88]. Copyright 1999 Nature Publishing group...

Zhang Y, Chu CC. In vitro release behavior of insulin from biodegradable hybrid hydrogel networks of polysaccharide and synthetic biodegradable polyester. J Biomater Appl 2002 16 305-325. 

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Yi, J. Z., and Zhang L. M. (2008). Removal of methylene blue dye from aqueous solution by adsorption onto sodium humate/pol3racrylamide/ clay hybrid hydrogels. Bioresource Technol.. 99, 2182-2186. 

Kopecek J, Yang J (2012) Smart self-assembled hybrid hydrogel biomaterials. Angew Chem IntEd51 73%-7417... 

Zhang, X. Z., G. M. Sun, et al. (2004). Temperature sensitive dendrite-shaped PNIPAAm/Dex-AI hybrid hydrogel particles formulation and properties. European Polymer Journal 40(9) 2251-2257. 

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