Mammary tumor cell

Vitamins and lipids are often required for animal cells to grow in serum-free medium. Phosphoethanolamine and ethanolamine are key additives that facilitate the growth of the mammary tumor cell line 64024 (Kano-Sueoka and Errick, 1981). In addition, ethanolamine promotes the growth of human lymphocytes and mouse hybridoma cells. Short-term cultures of human diploid lung and foreskin fibroblasts grow in medium that includes among its supplements soybean lecithin, cholesterol, sphingomyelin, and vitamin E. 

Recent observations suggest that carotenoids may modulate the AP-1 activation process. It has been recently reported in mammary tumor cell lines that [3-carotene and its cleavage products were able to decrease the activation of AP-1 (Tibaduiza et al., 2002). Moreover, lycopene was also shown to downregulate AP-1 in mammary cancer cells (Karas et al., 2000). In addition, a pharmacological... 

Graham CH, Kobayashi H, Stankiewicz KS, Man S, Kapitain SJ, Kerbel RS (1994) Rapid acqisition of multicellular drug resistance after a single exposure of mammary tumor cells to antitumor aklylating agents. J Natl Cancer Inst 86 975-982... 

Zhang S, Fulton AM. Modulation of integrin-laminin receptor function on mammary tumor cells by prostaglandin E2 receptor antagonism. Cancer Lett 1994 85 233-238. 

In the case of rat and human-breast cancer, an increase in serum-sialyltransferase activity is considered to be the consequence of both increased production and release, the latter perhaps through cell-surface shedding of the enzyme from the metastasizing, mammary-tumor cells.290 Accordingly, release of large amounts of sialyltransferase from hepatoma cell-lines derived from patients having hepatocellular carcinoma was observed, in contrast to cell lines derived from nomial human-liver.291 An increased level of sialyltransferase has been observed in regenerating rat-liver.292... 

Barnes D, Sato G (1979), Growth of a mammary tumor cell line in a serum-free medium, Nature 281 388-389. 

Ip, C., Ip, M.M., Loftus, T., Shoemaker, S., and Shea-Eaton, W., Induction of apoptosis by conjugated linoleic acid in cultured mammary tumor cells and premalignant lesions of the rat mammary gland, Cancer Epidemiol. Biomarkers Prev., 9, 689, 2000. 

Wonderlin WF, Woodfork KA, Stroble JS (1995) Changes in membrane potential during the progression of MCF-7 human mammary tumor cells through the cell cycle. J Cell Physiol 165 177-185... 

Wcm T47 D mammary tumor cells No physical damage, good reproducibility [73]... 

Belloc, C., Lu, H., Soria, C., Fridman, R., Legrand, Y. and Menashi, S. (1995). The effect of platelets on invasiveness and protease production of human mammary tumor cells. Int. J. Cancer 60, 413-417. 

A recent advance in this field has been reported by Yin, who has synthesized six new di-n-butyltin bis-heteroaromatic carboxylates (Figure 4.4.6) and tested them in vitro against the human mammary tumor cell line MCF-7. They are soluble in water and display quite high activity, much higher than that of cisplatin. 

Copper nc GR-mediated transactivation Mouse mammary tumor cell line 51... 

Because of its importance in tumor glycosylation and blood antigen structures, Fuc has attracted attention as a target for metabolic structural modification [75]. 2-Fluoro-Fuc was shown to be incorporated into glycoproteins in mouse fibroblasts [76]. Specific localization of 6-fluoro-Fuc in the Golgi apparatus, nuclear membrane, plasma membrane, and cytoplasm of human mammary tumor cells indicated glycoprotein incorporation there as well [54]. Likewise, the metabolites GDP-6-fluoro-Fuc and 6-fluoro-Fuc-l-phosphate have been directly observed in these cells. 

Ronai Z, Tillotson JK, Traganos F, et al. 1995. Effects of organic and inorganic selenium compounds on rat mammary tumor cells. Int J Cancer 63 428-434. 

In the case of MMTV, at least two loci, MTV-1 and MTV-2, located in GC-poor isochores (37-38%) are expressed as infectious viruses in GR (Bentvelzen et ah, 1970) and C3H (Van Nie and Verstaelen, 1975) strains of mice and in the GR mammary tumor cell line. Moreover, most mouse strains contain at least one copy of endogenous MMTV provirus (Marcus et ah, 1981) expressed not only in mammary glands during lactation (Choi et ah, 1987), but also in several organs at a lower level (Henrard and Ross, 1988). These data indicate that MMTV sequences can, indeed, be expressed when integrated in GC-poor isochores. 

Sundaram SC, Milner JA. Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture. Cancer Lett 1993 74 85-90. 

Palom, Y. et al., Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts the effect of dicwcmol, Biochem. Pharmacol, 61,1517, 2001. 

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