Macrophage stimulating protein human

Several other cell types have also been shown to secrete histamine-releasing activity, some of which may be peptide in nature (although more work is necessary for a definitive characterization). For example, human lung macrophages cultured for 24 h have been shown to release a soluble factor (12 and 30 kDa) that stimulates isolated human lung mast cells and human basophils to release histamine [ 145]. The generation and release of this factor developed over time (> 1 h) and was blocked by cycloheximide, indicating that protein... 

Edwards, S. W., Holden, C. S., Humphreys, J. M., Hart, C. A. (1989). Granulocyte-macrophage colony-stimulating factor (GM-CSF) primes the respiratory burst and stimulates protein biosynthesis in human neutrophils. FEBS Lett. 256,62-6. 

Aronica SM, Mantel C, Gonin R, et al. Interferon-inducible protein 10 and macrophage inflammatory protein-1 alpha inhibit growth factor stimulation of Raf-1 kinase activity and protein synthesis in a human growth factor-dependent hematopoietic cell line. J Biol Chem 1995 270 21998-2007. 

Several cytokines have been shown to enhance eotaxin mRNA expression and protein. Human eotaxin mRNA is expressed by umbilical vein endothelial cells, U937 monocytic cells, colonic epithelial cells, respiratory epithelial cell lines, and dermal fibroblasts following stimulation with cytokines such as TNFa, IL-ip and IFNy (40,85,86). The release of TNFa and IL-ip by alveolar macrophages from asthmatics (87,88) could be important in the upregulation of eotaxin mRNA and protein levels observed in this disease (79-81) and thus may define a mechanism linking inflammatory cytokine mobilization to eosinophil recruitment. 

Lapinet, J. A., Scapini, P., Calzetti, F., Perez, O., and Cassatella, M. A. (2000). Gene expression and production of tumor necrosis factor alpha, interleukin-1 beta (IL-lbeta), IL-8, macrophage inflammatory protein lalpha (MIP-lalpha), MIP-lbeta, and gamma interferon-inducible protein 10 by human neutrophils stimulated with group B meningococcal outer membrane vesicles. Infect. Immun. 68, 6917-6923. 

ACDy allergic contact dermatitis /CD, irritant contact dermatitis JL, interleukin HLA, human leukocyte antigen ICAMy intercellular adhesion molecule TNF, tumour-necrosis factor IFNy interferon GM-CSFy granulocyte-macrophage-colony-stimulating factor /P, IFN-induced protein M/P, macrophage inflammatory protein... 

A cDNA encoding adipophilin was identified in cultured human macrophages stimulated with oxidised LDL using mRNA differential display (Wang et al. 1999). Adipophihn is a 50 kDa protein known to be a specific marker for adipocyte cell differentiation and hpid accumulation in a variety of cells. The time-dependent induction of adipophilin mRNA in macrophages was specific to oxidised LDL but not native LDL, and not to various cytokines and serum. In human atherosclerotic lesions, adipophihn mRNA expression was locahsed in the subset of hpid-rich macrophages. 

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