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Stimulating Factors

A major cause of morbidity and mortality in patients who receive cytotoxic treatment or radiotherapy for cancer is bacterial and fungal infections. Intensive chemotherapy is associated with fever and infection, and the development of neutropenia further increases this risk of infection. Consequently, maximum doses of some cytotoxic drugs are limited due to bone marrow toxicity. Higher doses of chemotherapy and radiation therapy have become possible due to a reduction in bone marrow damage with the availability of the CSFs for clinical use. [Pg.48]

Ah = Antibody IL = interleukin TNF =tumornecrosis factor INF = interferon LAK =lymphocyte-activated killer CSF =colony stimulating factors and FGF = fibroblast growth factor. [Pg.41]

Cytokines and Immunophilins. A large number of inflammatory mediators and related proteins including the cytokines, colony stimulating factors (CSFs), interferons (IFNs), tumor necrosis factors (TNFs), growth factors (see Growth regulators), neurotrophic factors, and immunophilins are found in the mammalian CNS and appear to play a significant role in CNS function both in development and in aspects of brain homeostasis (40—43). [Pg.539]

Hematopoietic cytokines/colony-stimulating factors IL-3, IL-5, IL-6, IL-7, erythropoietin, GM-CSF, G-CSF, M-CSF, thrombo-poietin... [Pg.410]

Colony-stimulating factors Hematopoietic colony-stimulating factors... [Pg.579]

MecalfD (1990) The colony stimulating factors. Discovery, development, and clinical applications. Cancer 65 185-195... [Pg.581]

Armitage JO (1998) Emerging applications of recombinant human granulocyte colony-stimulating factor. Blood 92 4491-4508... [Pg.581]

Several cytokines are in clinical use that support immune responses, such as IL-2, DFNs, or colony-stimulating factors. IL-2 supports the proliferation and effector ftmction of T-lymphocytes in immune compromised patients such as after prolonged dialysis or HIV infection. IFNs support antiviral responses or antitumoral activities of phagocytes, NK cells, and cytotoxic T-lymphocytes. Colony-stimulatory factors enforce the formation of mature blood cells from progenitor cells, e.g., after chemo- or radiotherapy (G-CSF to generate neutrophils, TPO to generate platelets, EPO to generate erythrocytes). [Pg.616]

Neutropenia is a drop in the number of circulating leukocytes, especially neutrophils. It can be induced by a variety of drugs. Treatment with cytotoxic antineo-plastic drags usually results in severe neutropenia, which can be treated with colony-stimulating factors (G-CSF, GM-CSF). [Pg.846]

Cytokine receptors that couple to the JAK-STAT Pathway decode the signaling though hematopoietic cytokines (erythropoietin, thrombopoietin, colony-stimulating factors), prolactin, growth hormone, the a-, (3- and y- interferons, and a number of immunomodulatory interleukins [3], They form homodimetic or heterodimeric receptor complexes, which after ligandbinding recruit and activate isotypes of Janus kinases (JAKs). Activated JAKs in turn... [Pg.1238]

Colony-stimulating Factors Combinatorial Chemistry Compartment Competitive Antagonists Complement System Complement-type Repeat Complex Disease Compound Libraries Compound Optimization Computational Biology Computerized Tomography COMT... [Pg.1489]

Murine macrophage colony-stimulating factor obtained from mouse L cells can be purified more efficiently on a large scale by HPLC in the presence of sodium dodecyl sulfate. The adsorption on hydroxylapatite gel is dependent on the presence of sodium dodecyl sulfate [197]. [Pg.275]

Term to UltraLink granulocyte- macrophage colony-stimulating factor Concept type PRODUCT... [Pg.734]

Normalized term Granulocyte-macrophage colony-stimulating factor—Cangene Synonyms ... [Pg.734]

Granulocyte-macrophage colony -stimulating factor—Cangene... [Pg.734]

See other pages where Stimulating Factors is mentioned: [Pg.239]    [Pg.206]    [Pg.238]    [Pg.539]    [Pg.235]    [Pg.272]    [Pg.494]    [Pg.495]    [Pg.435]    [Pg.444]    [Pg.446]    [Pg.544]    [Pg.32]    [Pg.82]    [Pg.192]    [Pg.224]    [Pg.265]    [Pg.381]    [Pg.381]    [Pg.398]    [Pg.411]    [Pg.579]    [Pg.968]    [Pg.1082]    [Pg.23]    [Pg.734]    [Pg.734]    [Pg.734]    [Pg.734]    [Pg.734]    [Pg.736]    [Pg.736]    [Pg.736]    [Pg.742]    [Pg.742]   


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