Interferon-inducible protein

Denovan-Wright EM, Ferrier GR, Robertson HA, Hewlett SE. 2000. Increased expression of the gene for a-interferon inducible protein in cardiomyopathic hamster heart. Bio-chem Biophys Res Comm 267 103. 

Interferons are cellular glycoproteins produced by the host cells which exert complex antiviral, immunoregulatory and antiproliferative activities. After binding to interferon receptors it acts through cellular metabolic processes which involves synthesis of viral RNA and proteins. Interferon receptors are tyrosine protein kinase receptors which on activation phosphorylate cellular proteins. These then induce transcription of interferon induced proteins which exert antiviral effects. There are three type of interferons - alpha, beta and gamma. 

W6. Wang, X., Li, X., Schmidt, D. B., Foley, J. J., Barone, F. C., Ames, R. S., and Sarau, H. M., Identification and molecular characterization of rat CXCR3 Receptor expression and interferon-inducible protein-10 binding are increased in focal stroke. Mol. Pharmacol. 57, 1190—1198... 

Zhang, H.M., Yuan, J., Cheung, P., Chau, D., Wong, B.W., McManus, B.M., and Yang, D. (2005). Gamma interferon-inducible protein 10 induces HeLa cell apoptosis through a p53-dependent pathway initiated by suppression of human papillomavirus type 18 E6 and E7 expression. Mol Cell Biol 25, 6247-6258. 

Horton, M.R. et al., Hyaluronan fragments synergize with interferon-gamma to induce the C-X-C chemokines mig and interferon-inducible protein-10 in mouse macrophages, J. Biol. Chem., 273, 35088, 1998. 

Sarris, A. H., Broxmeyer, H. E., Wirthmueller, U., Karasavvas, N., Cooper, S., Lu, L., Krueger, J., and Ravetch, J. V. (1993) Human interferon-inducible protein 10 expression and purification of recombinant protein demonstrate inhibition of early human hematopoietic progenitors. J. Exp. Med. 178,1127-1132. 

X. Wang, T. L.Yue, E. H. Ohlstein, C. P. Sung, and G. Z. Feuerstein, Interferon-Inducible Protein-10 Involves Vascular Smooth Muscle Cell Migration, Proliferation, and Inflammatory Response, Journal of Biological Chemistry, 271 (1996) 24286-24293. 

Aronica SM, Mantel C, Gonin R, et al. Interferon-inducible protein 10 and macrophage inflammatory protein-1 alpha inhibit growth factor stimulation of Raf-1 kinase activity and protein synthesis in a human growth factor-dependent hematopoietic cell line. J Biol Chem 1995 270 21998-2007. 

Sgadari C, AngioliUo AL, Tosato G. Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10, Blood 1996 87 3877-82. 

MCP-1, MCP-3, MIP-1 (macrophage inflammatory protein-ip), IP-10 (interferon-inducible protein-10), iNOS (inducible nitric oxide synthase), and COX2 was suppressed [218],... 

Taub, D., Lloyd, A., Corion, K., Wang, J., Ortoldo, J., Harada, A., Matsushima, K., Kelvin, D., and Oppenheim, J., Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells, J. Exp. Med., 177, 1809, 1993. 

Sgadari C, Angiolillo AL, Cherney BW, Pike SE, Farber JM, Koniaris LG, Vanguri P, Burd PR, Sheikh N, Gupta G, Teruya-Feldstein J, Tosato G. Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo. Proc. Natl. Acad Sci. 93 13791-13796, 1996. 

Feldman AL, Friedl J, Lans TE, Libutti SK, Lorang D, Miller MS, Turner EM, Hewitt SM, Alexander HR. Retroviral gene transfer of interferon-inducible protein 10 inhibits growth of human melanoma xenografts. Int. J. Cancer 99 149-153, 2002. 

The physiological role of dihydrouridine, and, therefore, DUS, remains unknown, but it occurs throughout biology. Human DUS2 is upregulated in pulmonary carcinogenesis and inhibits the kinase activity of PKR, an interferon-induced protein kinase involved in the regulation of antiviral innate immunity. ... 

This is converted to an inactive phosphorylated form by a dsRNA-dependent protein kinase (Fig. 31-10). The protein kinase also appears to be an interferon-induced protein as is the oligo(2 -5 A)-activated RNAse indicated in Fig. 31-10. ° Interferons have effects other than inducing the antiviral state. Thus, human IFN-p2 is identical to a B-cell differentiation factor. Both IFN-a and IFN-p have antigrowth activity and are currently in use for treatment of some forms of cancer as well as for viral infections. ... 

Interferon -inducible protein 10 kDa (IP-IO/CXCLIO) is a chemokine that in solution, exists in equilibrium between monomer and dimer. A solution structure of a monomeric variant has been solved by NMR (Booth et al., 2002). However, like MCP-1, it has also been crystallized in different space groups, revealing tetrameric oligomerization states (Swaminathan et al., 2003). One of the forms is similar to the PF4 and MCP-1 tetramers. The other two tetramers form a novel twelve-stranded /3-sheet containing structure (Fig. 9), which the authors postulate could represent structures induced by binding of different GAGs. 

Taub DD, Lloyd AR, Conlon K, et al. Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothehal cells. J Exp Med 1993 177 1809—1814. 

Maghazachi AA, Skalhegg BS, Rolstad B, Al-Aoukaty A. Interferon-inducible protein-10 and lymphotactin induce the chemotaxis and mobilization of intracellular calcium in natural killer cells through pertussis toxin-sensitive and -insensitive het-erotrimeric G-proteins. EASED J 1997 11 765-774. 

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