Histamine secretion

Physiological response glycogen breakdown visual excitation histamine secretion in all allergic reactions slowing of pacemaker activity that controls the rate of the heartbeat... 

Fig. 2. Effects of increasing concentrations of anti-igE on histamine secretion from eieven preparations of HHMC from patients undergoing heart transpiantation. Each point represents the mean SEM. 

Calcium and histamine secretion from mast cells, 19 (1982) 59... 

In the mast cell, evidence for the mobilization of Ca from either extracellular or intracellular pools as an essential step in the initiation of histamine secretion comes from the following observations ... 

Saturation of the IgE-receptor by IgE or the removal of cell-bound IgE, has no observable effect on peptide stimulation of histamine secretion [86a]. 

Desensitization (inactivation) of mast cells to a particular peptide (for example, bradykinin) or to compound 48/80, desensitizes the mast cells to further stimulation by another peptide or by compound 48/80 but not to IgE-dependent stimulation [3,86a, 87]. This suggests that peptides (and 48/80) share a common mechanism of action in eliciting histamine secretion and that they compete for a common binding site. 

Results obtained in mucin-secreting goblet cells, which will be reviewed here, and in histamine-secreting mast cells, which have been presented elsewhere [2], are prompting us to abandon some long-established ideas about packing and release in secretion and to sketch a new hypothesis based on current polymer-gel theory. 

Kidd, M., Tang, L.H., Miu, K., Lawton, G.P., Sandor, A., Modlin, I.M. (1996). Autoregulation of enterochromaffin-like cell histamine secretion via the histamine 3 receptor subtype. Yale J. Biol. Med. 69, 9-19. 

Prinz, C., Kajimura, M., Scott, D.R., Mercier, F., Helander, H.F., Sachs, G., 1993. Histamine secretion from rat enterochromaffin-like cells. Gastroenterology 105, 449-461. 

Vuyyuru, L., Schubert, ML., Harrington, L., Arimura, A., Makhlouf, G.M., 1995. Dual inhibitory pathways link antral somatostatin and histamine secretion in human, dog, and rat stomach. Gastroenterology 109, 1566-1574. 

Decrease of histamine secretion from mast cells by inhibition of histidine decarboxylase... 

Pearce, F. L., Befus, A. D., and Bienenstock, J. Mucosal mast cells. III. Effect of quercetin and other flavonoids on antigen-induced histamine secretion from rat intestinal mast cells. J Allergy Clin Immunol, 73(6), 819-823, 1984. 

Presynaptic H3 heteroreceptors, when activated, inhibit the release of transmitter from several peripheral cholinergic neuron systems, probably preganglionic as well as postganglionic parasympathetic (Table 3). The receptors may be activated by histamine secreted from mast cells. 

Yano H, Nakanishi S, Kimura K et al (1993) Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J Biol Chem... 

Figure 4.2 Gastric add production. Two cell types in the mucosa of the corpus of stomach are principally responsible for secretion of acid. Histamine secreted from nearby enterochromaffin-like (ECL) cells stimulates parietal cells to secrete acid. A variety of substances can stimulate the ECL cell to secrete histamine, including PCAP, pituitary adenyl cyclase-activab ng peptide (released from enteric nervous system interneurones in the gastric mucosa), and gastrin, both stimulating ECL cells via adenyl cyclase to raise intracellular levels of cAMP that lead to histamine secretion.

Clegg, L.S., Church, M.K. and Holgate, S.T. (1985). Histamine secretion from human skin slices induced by anti-IgE and artificial secret ogues and the effects of sodium cromoglycate and salbutamol. Clin. Allergy 15, 321-328. 

Lau, L.C.K., Church, M.K., Walls, A.F. and Howarth, P.H. (1995). Dispersion and characterisation of mast cells from human nasal polyp and the effects of salbutamol and IBMX on histamine secretion induced by anti-IgE. Submitted. 

ZAKI, M., et al.. Somatostatin receptor subtype 2 mediates inhibition of gastrin and histamine secretion from human, dog, and rat antrum. Gastroenterology 111 (1996) 919-924. 

Fig. 5. Correlations between the maximum percent of histamine secretion and PGD2 and LTC4 release induced by protein Fv from human heart mast cells. Each point is the mean of duplicate determinations from separate experiments. (Reproduced with permission from Genovese et al. [58].)... 

Foreman JC. 1977. Spontaneous histamine secretion from mast cells in the presence of strontium. J Physiol 271 215-232. 

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