Tryptase-containing mast cell

M-CSF Monocyte/macrophage colony-stimulating factor MCt Tryptase-containing mast cell MCtc Tryptase- and chymase-containing mast cell MDA Malondialdehyde MDGF Macrophage-derived growth factor... 

Kaartinen M, Penttila A, Kovanen PT Accumulation of activated mast cells in the shoulder region of human coronary atheroma, the predilection site of atheromatous rupture. Circulation 1994 90 1669. Kaartinen M, Penttila A. Kovanen PT Mast cells of two types differing in neutral protease composition in the human aortic intima. Demonstration of tryptase- and tryptase/chymase-containing mast cells in normal intimas, fatty streaks, and the shoulder region of atheromas. Arterioscler Thromb 1994 14 966. 

The in-vitro inhibition activity of the synthesized target compounds against human mast cell tryptase is summarized in Tables 3.2.1 and 3.2.2 Compound 8, which contains aminomethyl benzyl moieties as head groups, was the most potent of the pyran series (type I), with a Ki value of 1.3 nM. Compared with 8, the tryptase inhibitors with aminomethylcyclohexyl substituents (17, 18, and 21), were 100-fold (Ki = 130 nM), 60-fold (Ki = 75 nM), and approximately 90-fold (Ki = 120 nM) less... 

Secretory granules of cardiac mast cells contain tryptase as well as histamine [31], We found a significant correlation between the maximum histamine and tryptase release indicating that protein Fv releases tryptase in parallel with... 

The two distinct types of mast cells in humans are distinguished by differences in their secretory granule protease constituents. cells contain chy-mase, carboxypeptidase, cathepsin G-like protease and tryptase. They are the predominant type of mast cells found in the skin and in the gastrointestinal submucosa. MC.p cells contain only tryptase and are the predominant type of mast cell found in the lung, particularly in the alveoli, and in the small intestinal mucosa (37,38). Although one of these mast cell types often predominates in a given tissue, smaller amounts of the other mast cell type are also usually present. In addition, the relative amount of each type of mast cell within the tissue may change with tissue inflammation or fibrosis (39). 

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