Human granulocyte-macrophage colony stimulating factor

Nemunaitis, J. et al., Use of recombinant human granulocyte-macrophage colony-stimulating factor in graft failure after bone marrow transplantation, Blood, 76, 245, 1990. 

Wing, E J. et al., Recombinant human granulocyte/macrophage colony-stimulating factor enhances monocyte cytotoxicity and secretion of tumor necrosis factor alpha and interferon in cancer patients, Blood, 73, 643, 1989. 

Lopez, A. F., Williamson, D. J., Gamble, J. R., Begley, C. G., Harlen, J. M., Klebanoff, S. J., Waltersdorph, A., Wong, G., Clark, S. C., Vadas, M. A. (1986). Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival. 

Raines, M. A., Liu, L. D., Quan, S. G., Joe, V., DiPersio, J. F., Golde, D. W. (1991). Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor. Proc. Natl. Acad. Sci. USA 88, 8203-7. 

Vadas, M. A. (1988). Recombinant human granulocyte-macrophage colony-stimulating factor (rH GM-CSF) regulates fMet-Leu-Phe receptors on human neutrophils. Immunol. 64,519-25. 

Walter M.R., Cook W.J., and Ealick S.E. (1992), Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor, J. Mol. Biol. 224, 1075-1085. 

Kaczmarski RS, Pazniak A, Lakhani A, Harvey E, Mufti GJ. 1993. A pilot study of low-dose recombinant human granulocyte-macrophage colony-stimulating factor in chronic neutropenia. Br J Hematol. 84 338-340. 

Hogge, G.S., Burkholder, J., Culp, J., Dubielzig, R.R., Albertini, M.R., Keller, E.T. et al. (1998) Development of human granulocyte macrophage-colony stimulating factor transfected tumor cell vaccines for the treatment of spontaneous canine cancer. Hum. Gene Ther., 9, 1851-1861. 

Kwon TH, Kim YS, Lee JH, Yang MS (2003), Production and secretion of biologically active human granulocyte macrophage-colony stimulation factor in transgenic tomato suspension cultures, Biotechnol. Lett. 25 1571-1574. 

Human Granulocyte-Macrophage colony-stimulating factor 0.25 mg H secreted Cell proliferation Heterogeneous [12]... 

Reactors of this type have been used to produce and harvest the heavy chain of a murine monoclonal antibody using protein G affinity and histidine-tagged human granulocyte-macrophage colony-stimulating factor (GM-CSF) using metal affinity chromatography. Implementation of this scheme on a small scale was difficult, but these studies show that the amount of recoverable protein can be increased [62]. As shown in Fig. 4, recoveries of human GM-CSF and a mouse monoclonal antibody heavy chain were increased by three- and seven-fold, re-... 

Kapp, A., Zeck Kapp, G., Danner, M., and Luger, T. A. (1988) Human granulocyte-macrophage colony stimulating factor An effective direct activator of human polymorphonuclear neutrophilic granulocytes. J. Invest. Dermatol. 91,49-55. 

Recombinant human granulocyte macrophage colony-stimulating factor o stimulates the production of neutrophils, monocytes/ macrophages, myeloid-derived dendritic cells... 

Woodcock, J. M., McClure, B. J., Stomski, F. C., Elliott, M.J., Bagley, C.J., and Lopez, A. F. (1997). The human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor exists as a preformed receptor complex that can be activated by GM-CSF, interleukin-3, or interleukin-5. Blood 90, 3005—3017. 

A. Tsarbopoulos, B. N. Pramanik, J. Labdon, P. Reichert, G. Gitlin, S. Patel, V. Sardana, T. L. Nagabhushan, and P. P. Trotta, Isolation and characterization of a resistant core peptide of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) confirmation of the GM-CSF amino acid sequence by mass spectrometry. Protein Sci. 2 (1993), 1948-1958. 

Hovgaard D, Mortensen BT, Schifter S, Nissen NI. Comparative pharmacokinetics of single dose administration of mammalian and bacterially-derived recombinant human granulocyte-macrophage colony stimulating factor. Eur J Haematol 1993 50 32-6. 

Moonen P, Mermod JJ, Ernst JF, Hirschi M, DeLamarter JF. Increased biological activity of deglycosylated recombinant human granulocyte-macrophage colony stimulating factor produced by yeast or animal cells. Proc Natl Acad Sci USA 1987 84 4428-31. 

Kauskansky K. Role of carbohydrate in the function of human granulocyte-macrophage colony stimulating factor. Biochemistry 1987 26 4861-7. 

Miniero R, Madon E, Artesani L, Busca A, Sandri A, Aglietta M, Ramenghi U. Acute pulmonary failure after the first administration of recombinant human granulocyte-macrophage colony-stimulating factor. Leukemia 1992 6(4) 352-3. 

Lieschke GJ, Maher D, Cebon J, O Connor M, Green M, Sheridan W, Boyd A, Railings M, Bonnem E, Metcalf D, et al. Effects of bacterially synthesized recombinant human granulocyte-macrophage colony-stimulating factor in patients with advanced malignancy. Ann Intern Med 1989 110(5) 357-64. 

Ragnhammar P, Friesen HJ, Frodin JE, Lefvert AK, Hassan M, Osterborg A, Mellstedt H. Induction of antirecombinant human granulocyte-macrophage colony-stimulating factor Escherichia co/i-derived) antibodies and clinical effects in nonimmunocompromised patients. Blood 1994 84(12) 4078-87. 

Leukine, rHu GM-CSF (Recombinant Human Granulocyte/Macrophage Colony-Stimulating Factor)... 

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