Lymphomas differential diagnosis

Suggested Alternatives for Differential Diagnosis Babesiosis, bacillary angiomatosis, cryptococcosis, Lyme disease, non-Hodgkin lymphoma, relapsing fever, Rocky Mountain spotted fever, tuberculosis, Ebstein-Barr virus, AIDS. 

Suggested Alternatives for Differential Diagnosis Blastomycosis, coccidioidomycosis, aspergillosis, pneumonia, respiratory distress syndrome, mediastinal cysts, mycoplasma infections, Pancoast syndrome, sarcoidosis, tuberculosis, lung abscess, lung cancer, lymphoma. 

M17. Matutes, E., Morilla, R., Owusu-Ankomah, K., Houlihan, A., and Catovsky, D., The immunophenotype of splenic lymphoma with villous lymphocytes and its relevance to the differential diagnosis with other B-cell disorders. Blood 83, 1558-1562 (1994). 

R15. Rudiger, T., Ott, G., Ott, M. M., Muller-Deubert, S. M., and Muller-Hermelink, H. K., Differential diagnosis between classic Hodgkin s lymphoma, T-cell-rich B-cell lymphoma, and paragranuloma by paraffin immunohistochemistry. Am. J. Surg. Pathol. 22, 1184-1191... 

Differential diagnosis of typhoid fever includes other Salmonella infections, leptospirosis, schistosomiasis, disseminated tuberculosis, malaria, brucellosis, viral hepatitis. Yersinia enterocolitis, influenza, lymphoma, toxoplasmosis, infectious mononucleosis, tuphus, encephalopathy and connective-tissue disorders. 

TABLE 53 Antibody Panel for Differential Diagnosis of Hodgkin Lymphoma ... 

Browne P, Petrosyan K, Hernandez A, et al. The B-cell transcription factors BSAP, Oct-2, and BOB.l and the pan-B-cell markers GD20, GD22, and GD79a are useful in the differential diagnosis of classic Hodgkin lymphoma. Am J Clin Pathol. 2003 120 767-777. 

Ki-67 antibodies recognize a nuclear protein involved in the proliferative portion of the cell cycle. They can be used as a measure of the growth fraction by dividing the number of positive cells by all cells present. This index roughly correlates with tumor grade and is important in the differential diagnosis of some tumors (e.g., Burkitt lymphoma). Correlations between Ki-67 index... 

This mitochondrial peroxisome enzyme, alpha-meth-ylacyl-CoA racemase (AMACR) (encoded by the gene P504S) catalyzes the racemization of alpha-methyl branched carboxylic coenzyme A thioesters and is present in prostate tissue and a wide variety of carcinomas (colorectal, ovarian, breast, bladder, lung, renal cell), melanoma, and lymphoma.AMACR is useful in prostate needle biopsies when the differential diagnosis... 

Neuroblastomas are small, round, blue cell tumors that may arise in the adrenal gland and a variety of extra-adrenal sites. The differential diagnosis is wide and includes rhabdomyosarcoma, Ewing s sarcoma-primitive neuroectodermal tumor (ES-PNET), medulloblastoma, small cell osteosarcoma, lymphoblastic lymphoma, blastematous Wilms tumor, and small cell desmoplastic tumor. Numerous markers have been used for the diagnosis of neuroblastomas including NE markers, cytoskeletal proteins, catecholamine-synthesizing enzymes, and neuroblastoma-"specific antibodies (Eig. 

The most helpful immunostain in this differential diagnosis—and one that the author, through regrettable mistakes, has made routine—is an assessment of keratin reactivity. The elaborately interconnecting epithelial cells of lymphocyte-predominant thymoma (LPT), which are not seen in LL, are distinctive. This pattern is essential to differential diagnosis, because LL and other lymphomas of thymus may demonstrate entrapped non-neoplastic thymic epithelial cells that are visible (but widely separated and non-interconnecting) on keratin immunostains. 3 Another potential marker for thymic epithelium—p63 protein" —is not as useful in this particular contextual setting. That is true because LL may be p63-reactive as well." ... 

FIGURE 11.18 Markers of interest in the differential diagnosis of carcinoma versus metastatic melanoma versus large-cell non-Hodg-kin lymphoma (LCL) versus seminoma of the mediastinum. 

Cerroni L, Goteri G. Differential diagnosis between cutaneous lymphoma and pseudolymphoma. Anal Quant Cytol Histol. 2003 25 191-198. 

Toyota N, Matsuo S, liztrka H. Immunohistochemical differential diagnosis between lymphocytoma cutis and malignant lymphoma in paraffin-embedded sections. J Dermatol. 1991 18 586-591. 

Multiple lesions can be produced by degenerative, vascular, and infectious diseases, or by neoplasms. Regarding neoplasms, the M-rule for differential diagnosis of common multiple central nervous system (CNS) neoplasms includes metastases, malignant lymphoma, melanoma, and medulloblastoma. ... 

In some cases, as in cerebral toxoplasmosis, which is frequently seen in HIV patients but may occur with at)q)ical manifestations, it is extremely important to do the differential diagnosis from several other neurological infections like lymphoma and other cancers (Montoya, 2002). 

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