Classical Hodgkin lymphoma

Loss of a pan-T cell antigen Abnormal CD4/CD8 only suggestive Classical Hodgkin lymphoma Expression of CD30 and CD 15 Lack of expression of CD45 B cell-antigen expression variable Precursor lymphoblastic leukemia/lymphoma TdT-positive... 

Hodgkin lymphoma (HL) is widely accepted to be a malignant clonal proliferation of B lymphocytes or, less often, T lymphocytes surrounded by variable numbers of inflammatory cells and fibrosis. The two major histologic types are classical Hodgkin lymphoma (CHL) and nodular lymphocyte predominance Hodgkin lymphoma (NLPHL). Classical Hodgkin lymphoma is further subdivided into four subtypes ... 

FIGURE 5.1 Classical Hodgkin lymphoma. (A) Lymphocyte rich. (B) Nodular sclerosis. (C) Lacunar cells in (D) Mixed cellularity. (E) Lymphocyte depletion. 

FIGURE 5.5 Absence of CD45/LCA (leukocyte common antigen) on Hodgkin/Reed-Sternberg cells in classical Hodgkin lymphoma. 

FIGURE 5.11 Detection of Epstein-Barr virus in classical Hodgkin lymphoma. (A) Expression of latent membrane protein-1 (LMP-1). (B) In situ hybridization studies for EBV encoded small RNAs known as EBER. 

FIGURE 5.13 junB expression in classical Hodgkin lymphoma. 

FIGURE 5.24 Diagnostic algorithm Classical Hodgkin lymphoma. 

Bakshi NA, Finn WG, Schnitzer B, et al. Fascin expression in diffuse large B-cell lymphoma, anaplastic large cell lymphoma, and classical Hodgkin lymphoma. Arch Pathol Lab Med. 2007 131 742-747. 

Browne P, Petrosyan K, Hernandez A, et al. The B-cell transcription factors BSAP, Oct-2, and BOB.l and the pan-B-cell markers GD20, GD22, and GD79a are useful in the differential diagnosis of classic Hodgkin lymphoma. Am J Clin Pathol. 2003 120 767-777. 

Tzankov A, Zimpfer A, Pehrs AG, et al. Expression of B-cell markers in classical Hodgkin lymphoma A tissue microarray analysis of 330 cases. Mod Pathol. 2003 16 1141-1147. 

Hertel CB, Zhou XG, Hamilton-Dutoit SJ, et al. Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma. Oncogene. 2002 21 4908-4920. 

Juszczynski P, Ouyang J, Monti S, et al. The API-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphoma. Proc Natl Acad Sci USA. 2007 104 13134-13139. 

Skinnider BE, Mak TW. The role of cytokines in classical Hodgkin lymphoma. Blood. 2002 99 4283-4297. 

Chute DJ, Cousar JB, Mahadevan MS, et al. Detection of immunoglobulin heavy chain gene rearrangements in classic Hodgkin lymphoma using commercially available BIOMED-2 primers. Diagn Mol Pathol. 2008 17 65-72. 

Savage KJ, Monti S, Kutok JL, et al. The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma. Blood. 2003 102 3871-3879. 

BL, Burkitt lymphoma BLL, Burkitt-like lymphoma cHL, classical Hodgkin lymphoma IL, immunoblastic lymphoma LBL-B, lymphoblastic lymphoma precursor B-cell LBL-T, lymphoblastic lymphoma precursor T-cell LPL, lymphoplasmacytic lymphoma MM, multiple myeloma N, almost always negative PCLBL, primary cutaneous large B-cell lymphoma PEL, primary effusion lymphoma pHL, lymphocyte predominance Hodgkin lymphoma P-PTLD, polymorphic posttransplant lymphoproliferative disorders P-TCL, peripheral T-cell lymphoma PTLD, posttransplant lymphoproliferative disorders. 

Buettner M, Greiner A, Avramidou A, et al. Evidence of abortive plasma cell differentiation in Hodgkin and Reed-Sternberg cell of classical Hodgkin lymphoma. Hematol Oncol. 2005 23 127-132. 

Bai M, Panoulas V, Papoudou-Bai A, et al. B-cell differentiation immunophenotypes in classical Hodgkin lymphomas. Leuk Lymphoma. 2006 47 495-501. 

Ushmorov A, Ritz O, Hummel N, Leithauser F, Moller P, Stein H, Wirth T. Epigenetic silencing of the immunoglobulin heavy-chain gene in classical Hodgkin lymphoma-derived cell lines contributes to the loss of immunoglobulin expression. Blood. 2004 104 3326-34. 

Fromm, J. R. Xhomas, A. Wood, B. L. Flow cytometry can diagnose classical Hodgkin lymphoma in lymph nodes with high sensitivity and specificity. Am. J. Clin. Pathol. 2009,131, 322-332. 

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