Small-cell osteosarcoma

Devaney K, Vinh TN, Sweet DE. Small cell osteosarcoma of bone An immunohistochemical study with differential diagnostic considerations. Hum Pathol. 1993 24 1211-1225. 

Neuroblastomas are small, round, blue cell tumors that may arise in the adrenal gland and a variety of extra-adrenal sites. The differential diagnosis is wide and includes rhabdomyosarcoma, Ewing s sarcoma-primitive neuroectodermal tumor (ES-PNET), medulloblastoma, small cell osteosarcoma, lymphoblastic lymphoma, blastematous Wilms tumor, and small cell desmoplastic tumor. Numerous markers have been used for the diagnosis of neuroblastomas including NE markers, cytoskeletal proteins, catecholamine-synthesizing enzymes, and neuroblastoma-"specific antibodies (Eig. 

In addition to the small-cell tumors presented in the foregoing sections, others of a metastatic nature also may involve the mediastinum. These include small-cell osteosarcoma and Ewing s sarcoma/primitive neuroectodermal tumor (PNET) of bone, as well as small-cell malignant melanoma. Except for the last of these possibilities, the primary lesion in such cases is typically obvious and there is no question of whether the intra-thoracic neoplasm might have arisen there. Nonetheless, melanomas are certainly capable of producing distant metastasis in the absence of an obvious primary source. 

RB1 Codes for the pRB protein, a master brake of Retinoblastoma, osteosarcoma, and bladder, small cell... 

Unlabeled Uses Adrenocortical, bladder, cervical, endometrial, prostatic, testicular carcinomas Ewing s sarcoma multiple sclerosis non-small cell, small cell lung cancer organ transplant rejection osteosarcoma ovarian germ cell, primary brain, trophoblastic tumors rheumatoid arthritis soft tissue sarcomas systemic dermato-myositis systemic lupus erythematosus Wilms tumor... 

Study of other rare hereditary cancers has led to the location of 20 or more additional probable tumor-suppressor genes. One of these, p53, is inactive in over 50% of all human cancers and over 90% of sqamous cell carcinomas of the skin.ee In small-cell lung cancers and osteosarcoma both RB and p53 are inactive.2 Protein p53 is a stronger tumor suppressor than protein Rb. Results of a variety of experiments have suggested that p53, a DNA-binding protein of known structure, plays a key role in checking DNA for damage at the C,... 

Malignant cartilage tumor Non-small-cell lung carcinoma Osteosarcoma Ovarian surface epithelial neoplasms Prostate cancer... 

Osteosarcoma Pancreatic cancer Small cell lung cancer ... 

Osteosarcoma is highly unusual outside the skeletal system. Like their intraosseous counterparts, extraskeletal osteosarcomas have a variety of histologic patterns, including fibroblastic, chondroblastic, small-cell, and telangiectatic images. 

Clear cell sarcoma, adenoid cystic carcinoma, small cell lung carcinoma, Ewing sarcoma, synovial sarcoma, osteosarcoma, angiosarcoma, AML,... 

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