Cyclin-dependant kinase inhibitor

Barres BA, Lazar MA, Raff MC 1994 A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development. Development 120 1097-1108 deNooij JC, Letendre MA, Hariharan IK 1996 A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis. Cell 87 ... 

Durand B, Gao FB, Raff M 1997 Accumulation of the cyclin-dependent kinase inhibitor p27/ Kipl and the timing of oligodendrocyte differentiation. EMBO J 16 306-317 Durand B, Fero ML, Roberts JM, Raff MC 1998 p27Kipl alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation. Curr Biol 8 431-440... 

Hong Y, Roy R, Ambros V 1998 Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegant. Development 125 3585—3597... 

Kiyokawa H, Kineman RD, Manova-Todorova KO et al 1996 Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kipl). Cell 85 721—732 KondoT, RaffM 2000a The Id4 HLH protein and the timing of oligodendrocyte differentiation. EMBO J 19 1998-2007... 

Kondo T, Raff M 2000b Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science 289 1754-1757 Lane ME, Sauer K, Wallace K, Jan YN, Lehner CF, Vaessin H 1996 Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development. Cell 87 1225-1235... 

Since the initial reports of HSQC-1,1-ADEQUATE spectra are very recent,49,50 there are only the reports by the author and co-workers in the literature. Aside from the initial work done using strychnine (1) as a model compound, applications to the complex antifungal agent posaco-nazole (47)96 and the cyclin-dependant kinase inhibitor dinaciclib (48)97 are the only other applications that have been reported. 

Application to the cyclin-dependant kinase inhibitor dinaciclib... 

Cyclin-dependent kinase Inhibitor analog Purine 22... 

Tomoda, K., Kubota, Y., Kato, J. Degradation of the cyclin-dependent-kinase inhibitor p27Kipl is instigated by Jabl. Nature 1999, 398, 160-165. 

Leclerc, S., Garnier, M., Hoessel, R. (2001) et al. Indirubins inhibit glycogen synthase kinase-3 3 and CDK5/P25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer s disease. A property common to most cyclin-dependent kinase inhibitors. J. Biol. Chem., 276, 251-260. 

Dai Y, Grant S. Cyclin-dependent kinase inhibitors. Curr Opin Pharmacol 2003 3 362-70. 

Vlach, J., Heimecke, S. and Amati, B. (1997). Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Kipl. EMBO J. 15, 5987-5997. 

Tyers, M. (1996). The cyclin-dependent kinase inhibitor p40 imposes the requirement for CLN G1 cyclin function at Start., Proc Natl Acad Sci USA 93, 7772-7776. 

Chiarle, R., Budel, L. M., Skolnik, J., Frizzera, G., Chilosi, M., Corato, A., Pizzolo, G., Magidson, J., Montagnoli, A., Pagano, M., et al. (2000). Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma. Blood 95, 619-626. 

Kiyokawa, H., Kineman, R., Manova-Todorova, K., Soares, V., Hoffman, E., Onoi, M., Hayday, A., Frohman, D., and Koff, A. (1996). Enhancehd growth of mice lacking the cyclin-dependent kinase inhibitor function of p27Kipl, Cell 85, 721-732. 

Lee, M., Reynisdottir, I., and Massague, J. (1995). Cloning of p57 , cyclin dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev 9, 639-649. 

Nguyen, H., Gitig, D. M., and Koff, A. (1999). Cell-free degradation of p27(kipl), a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome. Mol Cell Biol 19, 1190-1201. 

Pagano, M Tam, S., Theodoras, A., Beer, P Delsal, S., Chau, I., Yew, R., Draetta, G., and Rolfe, M. (1995). Role of the Ubiquitin-Proteasome pathway in regulating abundance of the Cyclin-dependent kinase inhibitor p27. Science 269,682-685. 

Russo, A. A., Jeffrey, P. D., Patten, A. K., Massague, J., and Pavletich, N. P. (1996). Crystal structure of the p27Kipl cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex [see comments]. Nature 382,325-31... 

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